| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
In the mouse ovary, neonatal exposure to estrogens or endocrine disruptors result in reproductive abnormalities including anovulation, hypertrophy-hyperplasia of the interstitial tissues and induction of polyovular follicles due to the alterations of hypothalamus-pituitary-axis. Our previous reports show that neonatal diethylstilbestrol (DES) exposure causes defeminization in the hypothalamus of female mice, however, the regulation of the pituitary gonadotropins is different from that in male mice. To investigate the effects of neonatal exposure to DES on the hypothalamus, immunohistochemistry of neurokinin B and estrogen receptor α was performed in DES-treated mice. In addition, microarray analysis revealed that neonatal DES treatment induced changes in the gene expression of the hypothalamus.
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