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Investigation of the neuroendocrinological basis involved in the regulation of the newt courtship behavior

Research Project

Project/Area Number 15K07135
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Morphology/Structure
Research InstitutionToho University

Principal Investigator

HASUNUMA Itaru  東邦大学, 理学部, 講師 (40434261)

Research Collaborator TOYODA Fumiyo  
YAMAMOTO Kazutoshi  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsアルギニンバソトシン / アルギニンバソトシン受容体 / アンドロジェン / プロラクチン / 求愛行動 / アカハライモリ / 視索前野
Outline of Final Research Achievements

In the breeding season, sexually developed male newt vibrates its tail in front of the female partner at an early stage of courtship behavior. This behavior is elicited by several hormonal factors such as prolactin and arginine vasotocin (AVT), and androgen. However, the mechanism of the regulation of courtship behavior by these hormones is still unkonwn. In this study, we have obtained following results: 1) It was revealed that androgen up-regulates the expression of AVT precursor gene in the preoptic area of the brain of male newt. 2) It was confirmed that the expression of four-types of AVT receptors in the newt brain, including V2b-type receptor, which is identified as a novel AVT receptor subtype. 3) It was revealed that the numbers of phospho-ERK1/2-immunoreactive cells increased in the medial pallium and bed nucleus of the stria terminalis in the telencephalon, preoptic area and ventral and dorsal hypothalamic nuclei in the diencephalon during courtship behavior.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (15 results)

All 2018 2017 2016 2015 Other

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 2 results) Presentation (11 results) (of which Int'l Joint Research: 1 results) Remarks (1 results)

  • [Journal Article] Imorin: A sexual attractiveness pheromone in female red-bellied newts (Cynops pyrrhogaster)2017

    • Author(s)
      Nakada, T., Toyoda, F., Matsuda, K., Nakakura, T., Hasunuma, I., Yamamoto, K., Onoue, S., Yokosuka, M. and Kikuyama, S.
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 41334-41334

    • DOI

      10.1038/srep41334

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Arginine vasotocin is the major adrenocorticotropic hormone-releasing factor in the bullfrog Rana catesbeiana.2016

    • Author(s)
      Okada. R., Yamamoto, K., Hasunuma, I., Asahina, J., Kikuyama, S.
    • Journal Title

      General and Comparative Endocrinology

      Volume: 237 Pages: 121-130

    • DOI

      10.1016/j.ygcen.2016.08.014

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Possible hormonal interaction for eliciting courtship behavior in the male newt, Cynops pyrrhogaster2015

    • Author(s)
      Toyoda, F., Hasunuma, I., Nakada, T., Haraguchi, S., Tsutsui, K., Kikuyama, S.
    • Journal Title

      General and Comparative Endocrinology

      Volume: 224 Pages: 96-103

    • DOI

      10.1016/j.ygcen.2015.06.016

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] アカハライモリ新規プロラクチン受容体遺伝子の同定2018

    • Author(s)
      須藤百合子、池田卓聡、岩室祥一、菊山榮、蓮沼至
    • Organizer
      日本動物学会関東支部第70回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] アカハライモリのアルギニンバソトシンV2b受容体の発現とその機能2017

    • Author(s)
      小野慧, 豊田ふみよ, 岩室祥一, 菊山榮, 蓮沼至
    • Organizer
      日本動物学会第69回関東支部大会
    • Place of Presentation
      筑波大学文京キャンパス(東京都・文京区)
    • Year and Date
      2017-03-11
    • Related Report
      2016 Research-status Report
  • [Presentation] アカハライモリ脳内アルギニンバソトシンV2bタイプ受容体の発現2017

    • Author(s)
      小野慧、豊田ふみよ、岩室祥一、菊山榮、蓮沼至
    • Organizer
      日本動物学会第88回富山大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] アカハライモリ脳および下垂体におけるアルギニンバソトシンV2bタイプ受容体の発現2017

    • Author(s)
      小野慧、中島康人(本学学生)、豊田ふみよ、岩室祥一、菊山榮、蓮沼至
    • Organizer
      第42回日本比較内分泌学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 両生類3型甲状腺刺激ホルモン放出ホルモン受容体(TRHR3)の構造と機能の解析2017

    • Author(s)
      中野真樹、蓮沼至、皆川温子、岩室祥一、山本和俊、菊山榮、町田武夫、小林哲也
    • Organizer
      第42回日本比較内分泌学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] プロラクチンのイモリ脳内細胞の分裂活性におよぼす影響2017

    • Author(s)
      大和田孝祐、豊田ふみよ、岩室祥一、菊山榮、蓮沼至
    • Organizer
      第42回日本比較内分泌学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] イモリ間脳視索前野AVT前駆体mRNA発現へのプロラクチンおよび雄性ホルモンの影響2016

    • Author(s)
      西井淳雄、小野慧、豊田ふみよ、山本和俊、岩室祥一、菊山榮、蓮沼至
    • Organizer
      第41回日本比較内分泌学会大会及びシンポジウム
    • Place of Presentation
      北里大学相模原キャンパス(神奈川県・相模原市)
    • Year and Date
      2016-12-10
    • Related Report
      2016 Research-status Report
  • [Presentation] Prolactin acts directly on the thyroid gland of larval bullfrogs to suppress its function.2016

    • Author(s)
      Hayama S, Watanabe T, Yamamoto K, Iwamuro S, Kikuyama S, Hasunuma I.
    • Organizer
      Joint meeting of the 22nd International Congress of Zoology and the 87th meeting of the Zoological Society of Japan
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県・宜野湾市)
    • Year and Date
      2016-11-17
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] ウシガエル幼生甲状腺のサイロキシン放出におよぼすプロラクチンの影響2016

    • Author(s)
      葉山舜, 山本和俊, 菊山榮, 岩室祥一, 蓮沼至
    • Organizer
      第2回次世代両生類研究会
    • Place of Presentation
      岡崎コンファレンスセンター(愛知県・岡崎市)
    • Year and Date
      2016-08-09
    • Related Report
      2016 Research-status Report
  • [Presentation] プロラクチンが関与する雄アカハライモリ脳内の細胞増殖メカニズム2016

    • Author(s)
      大和田孝祐、豊田ふみよ、山本和俊、菊山榮、岩室祥一、蓮沼至
    • Organizer
      日本動物学会第68回関東支部大会
    • Place of Presentation
      神奈川大学(神奈川県横浜市)
    • Year and Date
      2016-03-12
    • Related Report
      2015 Research-status Report
  • [Presentation] アカハライモリ脳内細胞分裂に及ぼすプロラクチンの影響2015

    • Author(s)
      大和田孝祐、豊田ふみよ、山本和俊、菊山榮、蓮沼至
    • Organizer
      日本動物学会第86回大会
    • Place of Presentation
      朱鷺メッセ(新潟県新潟市)
    • Year and Date
      2015-09-19
    • Related Report
      2015 Research-status Report
  • [Remarks] 東邦大学理学部生物学科生体調節学研究室

    • URL

      http://www.lab.toho-u.ac.jp/sci/bio/regl/

    • Related Report
      2017 Annual Research Report 2016 Research-status Report 2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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