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identification of hypothalamic melanin concentrating hormon neural circuit involving sleep reguration.

Research Project

Project/Area Number 15K07140
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Animal physiology/Animal behavior
Research InstitutionTokai University

Principal Investigator

Terao Akira  東海大学, 札幌教養教育センター, 教授 (10451402)

Co-Investigator(Kenkyū-buntansha) 岡松 優子  北海道大学, 獣医学研究院, 講師 (90527178)
Co-Investigator(Renkei-kenkyūsha) YAMANAKA AKIHIRO  名古屋大学, 環境医学研究所, 教授 (60323292)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords睡眠 / 記憶 / 絶食 / 視床下部外側野 / 海馬 / 新規物体認知試験 / 恐怖条件付け試験 / メラニン凝集ホルモン / 長期記憶 / 文脈的恐怖条件付け試験 / MCH / 断眠
Outline of Final Research Achievements

Melanin concentrating hormone (MCH) producing neurons project widely throughout the brain, including hippocampus, and control sleep. As sleep is suggested to link to memory and the hippocampus is crucial for memory, possible involvements of MCH neurons in spatial recognition memory formation were examined. MCH neuron ablated mice spent more time for exploration of a novel object relative to a familiar object, compared to the control mice. Moreover, MCH neuron ablated mice given foot-shock-conditioned fear memory showed higher freezing rate than the control mice. On the other hand, MCH neuron ablated mice stayed almost the same time in the center square of open field arena and in the open arms of elevated plus maze, as the control mice. The findings suggest that MCH neurons control hippocampus dependent spatial recognition memory negatively. As MCH neurons are active in sleep period, there is a possibility that MCH neurons delete some memory in sleep.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (15 results)

All 2017 2016 2015

All Journal Article (7 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 5 results,  Acknowledgement Compliant: 3 results) Presentation (8 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results)

  • [Journal Article] Progesterone dose-dependently modulates hepatocyte growth factor production in 3T3-L1 mouse preadipocytes2017

    • Author(s)
      Ito, T., Yamaji, D., Kamikawa, A., Abd Eldaim, M. A., Okamatsu-Ogura, Y., Terao A., Saito, M., and Kimura, K.
    • Journal Title

      Endocrine J

      Volume: 64 Pages: 777-785

    • NAID

      130006026350

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 睡眠とサイトカイン2017

    • Author(s)
      寺尾 晶
    • Journal Title

      小児内科

      Volume: 49 Pages: 1088-1091

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Royal jelly ameliorates diet-induced obesity and glucose intolerance by promoting brown adipose tissue thermogenesis in mice2017

    • Author(s)
      Yoneshiro T, Kaede R, Nagaya K, Aoyama J, Saito M, Izawa S, Okamatsu-Ogura Y, Kimura K, Terao A
    • Journal Title

      Obe Res Clin Pract

      Volume: Epub ahead of print Issue: 1 Pages: 127-137

    • DOI

      10.1016/j.orcp.2016.12.006

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Retinoic acid modulates lipid accumulation glucose concentration-dependently through inverse regulation of SREBP-1 expression in 3T3L1 adipocytes2017

    • Author(s)
      Abd Eldaim, M. A., Okamatsu-Ogura, Y., Matsuoka, S., Kamikawa, A, Ahmed, M., M., Terao, A., Nakajima, K., and Kimura, K.
    • Journal Title

      Genes Cells

      Volume: 印刷中

    • NAID

      120006477490

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 不眠症治療薬の薬理~歴史的変遷と今後の展望~2016

    • Author(s)
      寺尾 晶
    • Journal Title

      函館病院薬剤師会報

      Volume: 34 Pages: 9-13

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Progressive loss of the orexin neurons reveals dual effects on wakefulness2016

    • Author(s)
      Branch, A. F., Navidi, W., Tabuchi, S., Terao, A., Yamanaka, A., Scammell, T. E., and Behn, C. D.
    • Journal Title

      Sleep

      Volume: 39 Issue: 2 Pages: 369-377

    • DOI

      10.5665/sleep.5446

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 炎症性サイトカインのNREM睡眠調節機構2016

    • Author(s)
      寺尾 晶
    • Journal Title

      睡眠医療

      Volume: 10 Pages: 27-33

    • Related Report
      2015 Research-status Report
  • [Presentation] Temporally Controlled Cell-Specific Ablation Of Melanin-Concentrating Hormone (MCH) Neurons Attenuate Non-REM Sleep In Mice2017

    • Author(s)
      Terao, A., Ueno, T., Okamatsu-Ogura, Y., Kimura, K., Tsunematsu T., and Yamanaka, A.
    • Organizer
      31st Annual Meeting of the Associated Professional Sleep Societies
    • Related Report
      2017 Annual Research Report
  • [Presentation] Conditional ablation of melanin-concentrating hormone neurons attenuate NREM sleep in mice2016

    • Author(s)
      Terao, A. Ueno, T. Kimura, K. and Yamanaka, A.
    • Organizer
      23rd Congress of the European Sleep Research Society
    • Place of Presentation
      Bologna Congressi
    • Year and Date
      2016-09-14
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 視床下部メラニン凝集ホルモン産生神経の選択的脱落はノンレム睡眠を減少させる2016

    • Author(s)
      寺尾 晶、上野貴文、岡松優子、木村和弘、常松友美、山中章弘
    • Organizer
      第41回 日本睡眠学会
    • Place of Presentation
      京王プラザホテル東京
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 視床下部神経ペプチドによる睡眠覚醒調節2016

    • Author(s)
      寺尾 晶
    • Organizer
      第24回 北海道睡眠研究会
    • Place of Presentation
      京王プラザホテル札幌
    • Year and Date
      2016-04-23
    • Related Report
      2016 Research-status Report
  • [Presentation] Role of melanin-concentrating hormone neurons in the regulation of sleep2015

    • Author(s)
      Terao, A., Ueno, T., Kimura, K., and Yamanaka, A.
    • Organizer
      The 7th World Congress of the World Sleep Federation
    • Place of Presentation
      イスタンブール国際会議場(イスタンブール、トルコ)
    • Year and Date
      2015-11-03
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] エネルギー過剰状態におけるオレキシン産生細胞の制御2015

    • Author(s)
      寺尾 晶
    • Organizer
      第40回 日本睡眠学会
    • Place of Presentation
      宇都宮東武ホテルグランデ(栃木県、宇都宮市)
    • Year and Date
      2015-07-03
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 炎症性サイトカインの睡眠調節機構2015

    • Author(s)
      寺尾 晶
    • Organizer
      第40回 日本睡眠学会
    • Place of Presentation
      宇都宮東武ホテルグランデ(栃木県、宇都宮市)
    • Year and Date
      2015-07-02
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 不眠症治療薬の薬理~歴史的変遷と今後の展望~2015

    • Author(s)
      寺尾 晶
    • Organizer
      第300回函館病院薬剤師会例会・学術講演会
    • Place of Presentation
      ベルクラシック函館(北海道、函館市)
    • Year and Date
      2015-06-24
    • Related Report
      2015 Research-status Report
    • Invited

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Published: 2015-04-16   Modified: 2019-03-29  

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