| Project/Area Number |
15K07141
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | Hokkaido University of Education |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 昆虫 / 行動学 / 脳・神経 / 遺伝子 / ショウジョウバエ / 成熟 / 生殖行動 / ドーパミン / 神経回路網 |
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| Outline of Final Research Achievements |
In Drosophila, a female exhibits a typical repertoire of reproductive behavior. After copulation, the mated female lays eggs, at which she bends her abdomen downward and inserts the ovipositor into the substrate. A sex determination factor, doublesex (dsx), establishes the neural circuitry underlying the female reproductive behavior. Here, we will address whether dopaminergic neurons modulate the reproductive behavior. A pale gene encodes tyrosine hydroxylase (TH), the rate-limiting enzyme for dopamine synthesis. Activation of all pale-expressing neurons induced reproductive behavior in females. Also, activation of neurons co-expressing dsx and Dopamine receptors such as DopR or DopR2 induced parts of the reproductive behavior. Dopaminergic (pale-expressing) neurons possibly modulate the distinct sets of abdominal dsx-expressing neurons through the specific expression of the dopamine receptor, DopR or DopR2, that regulates the different elements of female reproductive behavior.
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