| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
A variety of external signals interpreted into defined neural functions play important role in the refinement of the neural function. Much remains to be understood how external signals contribute to the formation of the efficient neural system that supporting the transformation of the appropriate behavioral response against the complicated stimulus. Planarians display behaviors responsive to signals coming from outside such as light avoidance behavior, and the nervous system can be regenerated and its function completely restored even after decapitated, since the extraordinary regenerative capacity of planarians. We analyzed the molecular mechanisms of behavioral recovery during brain regeneration using RNAi and a behavioral assay in the planarian. Here we show that the novel neuropeptides contribute to the restitution of the proper phototactic behavior by modulating the photo-recognition during brain regeneration.
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