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Regulatory mechanism of male fertility by seminal fluid

Research Project

Project/Area Number 15K07159
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Genetics/Chromosome dynamics
Research InstitutionOkayama University

Principal Investigator

Nakagoshi Hideki  岡山大学, 自然科学研究科, 教授 (50314662)

Research Collaborator KUBO Ayuko  
MATSUKA Mirai  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsショウジョウバエ / 妊性 / 精液 / 栄養 / 細胞死 / 栄養シグナル / 転写制御因子 / タンパク質分解
Outline of Final Research Achievements

The male reproductive organ accessory glands in Drosophila make components of seminal fluid. We examined the possibility that accessory gland cells function as a nutrient sensor when controlling reproductive ability (fecundity) in response to nutrient conditions. Of the main cells (~ 1,000) and the secondary cells (~ 60), we showed that the nutrient conditions during development change the number and size of secondary cells to optimize male fecundity. In addition, Dve and Abd-B were identified as factors that control gene expression in a nutrient-dependent manner.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (9 results)

All 2018 2017 2016 2015 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results) Presentation (6 results) (of which Int'l Joint Research: 1 results) Remarks (1 results)

  • [Journal Article] Nutrient conditions sensed by the reproductive organ during development optimize male fecundity in Drosophila2018

    • Author(s)
      Kubo, A., Matsuka, M., Minami, R., Kimura, F., Sakata-Niitsu, R., Kokuryo, A., Taniguchi, K., Adachi-Yamada, T., and Nakagoshi, H.
    • Journal Title

      Genes to Cells

      Volume: (印刷中)

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spalt-mediated dve repression is a critical regulatory motif and coordinates with Iroquois complex in Drosophila vein formation2016

    • Author(s)
      Seiko Sugimori, Aya Hasegawa, and Hideki Nakagoshi
    • Journal Title

      Mechanisms of Development

      Volume: 141 Pages: 25-31

    • DOI

      10.1016/j.mod.2016.06.004

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Nutrient sensor in the reproductive organ regulates male fecundity in Drosophila2018

    • Author(s)
      Mirai Matsuka., Ayuko Kubo, Kiichiro Taniguchi, Takashi Adachi-Yamada, Hideki Nakagoshi
    • Organizer
      RIKEN CDB Symposium 2018, Kobe, Japan
    • Related Report
      2017 Annual Research Report
  • [Presentation] ショウジョウバエ生殖器官の栄養センサーはオスの妊性を制御する2017

    • Author(s)
      松家未来,久保愛結子,谷口喜一郎,安達卓,中越英樹
    • Organizer
      ConBio2017: 生命科学系学会合同年次大会 (神戸)
    • Related Report
      2017 Annual Research Report
  • [Presentation] ショウジョウバエ附属腺での小胞体ストレスの制御2016

    • Author(s)
      高橋紗央里,木村文香,谷口喜一郎,安達卓,中越英樹
    • Organizer
      日本分子生物学会第39回年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-11-30
    • Related Report
      2016 Research-status Report
  • [Presentation] Nutrient condition modulates male fecundity through changes of accessory gland cells in Drosophila2016

    • Author(s)
      Ayuko Kubo, Kiichiro Taniguchi, Takashi Adachi-Yamada, Hideki Nakagoshi
    • Organizer
      The 22nd International Congress of Zoology
    • Place of Presentation
      Okinawa, Japan
    • Year and Date
      2016-11-15
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] ショウジョウバエ附属腺におけるストレス応答と妊性の制御2015

    • Author(s)
      高橋紗央里,木村文香,松家未来,中越英樹
    • Organizer
      日本分子生物学会第38回年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] 栄養センサーとしてのショウジョウバエ雄の附属腺2015

    • Author(s)
      久保愛結子,谷口喜一郎,安達卓,中越英樹
    • Organizer
      日本動物学会第86回大会
    • Place of Presentation
      新潟
    • Year and Date
      2015-09-17
    • Related Report
      2015 Research-status Report
  • [Remarks] 中越研究室ホームページ

    • URL

      https://sites.google.com/view/nakagoshi-lab-hp

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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