| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Nuclear DNA haplotype structure analyses in the Japanese wild mice yielded a possible average fragment length of 170 kb of Mus musculus castaneus haplotypes in the M. m. musculus background genome in northern Japan, providing a rough estimate of its elapsed time of 800 generations under an assumption of continued backcrossing. Our analyses showed sporadic appearance of long fragments (2-5 Mb) from the west European subspecies Mus musculus domesticus, indicating contemporary stowaway introduction. In melanistic rats found on Okinawa, a predicted loss-of-function mutation caused by a cysteine to serine amino acid change at p.124C>S (c.370T>A) in the highly conserved functional domain of Asip was suggested to be responsible for the observed melanism. A haplotype structure analysis suggested the possibility of in-situ mutation of the Asip gene within the population on Okinawa.
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