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Establishment of primate model for progeroid syndromes derived from sporadic patient Japanese monkeys

Research Project

Project/Area Number 15K07235
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Physical anthropology
Research InstitutionKyoto University

Principal Investigator

Oishi Takao  京都大学, 霊長類研究所, 准教授 (40346036)

Research Collaborator HIRAI Hirohisa  
IMAMURA Masanori  
GO Yasuhiro  
DONG Cho  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords早老症 / モデル動物 / ニホンザル / ムコ多糖症 / リソソーム病 / 自然発症 / 動物モデル / 難病
Outline of Final Research Achievements

To identify the cause of progeroid symptoms of a Japanese monkey N416 (PLos One, 2014), element contents were measured in various organs. Amount of zinc in the heart, the liver, the kidney, but not in the lung or the cerebral cortex, or the hippocampus of N416, were lower than in that of normal monkeys. As zinc is essential for functions of DNA repair enzymes or antioxidant enzymes, low contents of zinc in these organs may lead to premature aging symptoms, though it does not account for shrinkage of the brain. Three Japanese monkeys, Mff2389 and two sisters, show gargoyle face. X-ray analysis and urine test supported that they suffer from mucopolysaccharidosis (MPS). Exosome analysis suggested that a homozygous missense mutation in IDUA gene lead to the symptoms in Mff2389. Genotype test showed that the sisters of Mff2389 were homozygous and half of the non-pedigree were heterozygous. This group can be a good source for the primate model for MPS, type I.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (10 results)

All 2018 2017 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (7 results) (of which Invited: 2 results) Book (1 results)

  • [Journal Article] Neuroscience Research with Nonhuman Primates : Differences and Similarities2016

    • Author(s)
      大石高生
    • Journal Title

      Japanese Journal of Neurosurgery

      Volume: 25 Issue: 6 Pages: 480-484

    • DOI

      10.7887/jcns.25.480

    • NAID

      130005158555

    • ISSN
      0917-950X, 2187-3100
    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Increased expression of the growth-associated protein-43 gene after primary motor cortex lesion in macaque monkeys.2015

    • Author(s)
      Murata Y, Higo N, Oishi T, Isa T.
    • Journal Title

      Neuroscience Research

      Volume: 98 Pages: 64-69

    • DOI

      10.1016/j.neures.2015.04.007

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Mucopolysaccharidosis in captive Japanese monkey at Primate Research Institute, Kyoto University2018

    • Author(s)
      大石高生、兼子明久、宮部貴子、今井啓雄、平崎鋭矢、郷康広、今村公紀、 木下こづえ、釜中慶朗、橋本直子、森本真弓、高田昌彦
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 霊長類研究所における遺伝病疑い家系に関する報告2017

    • Author(s)
      大石高生、兼子明久、宮部貴子、今井啓雄、平崎鋭矢、郷康広、今村公紀、木下こづえ、釜中慶朗、橋本直子、森本真弓、平井啓久、高田昌彦
    • Organizer
      第6回生理研・霊長研・脳研合同シンポジウム
    • Place of Presentation
      新潟市
    • Year and Date
      2017-03-09
    • Related Report
      2016 Research-status Report
  • [Presentation] 霊長類研究所における遺伝病疑い家系に関する報告2017

    • Author(s)
      大石高生、兼子明久、宮部貴子、今井啓雄、平崎鋭矢、郷康広、今村公紀、 木下こづえ、釜中慶朗、橋本直子、森本真弓、平井啓久、高田昌彦
    • Organizer
      第6回生理研-霊長研-脳研合同シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] サル輪状軟骨の元素蓄積の特徴2016

    • Author(s)
      東超、大石高生、東野義之、東野勢津子、南武志、西真弓
    • Organizer
      第121回日本解剖学会
    • Place of Presentation
      ビッグパレットふくしま(福島県、郡山市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Research-status Report
  • [Presentation] 「早老症」モデルニホンザル、シワコについて2015

    • Author(s)
      大石高生
    • Organizer
      第12回NBR公開シンポジウム
    • Place of Presentation
      フクラシア東京ステーション(東京都、東京)
    • Year and Date
      2015-12-11
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] ヒト脳と類人猿脳における時空間的比較トランスクリプトーム解析2015

    • Author(s)
      郷康広、辰本将司、Qian Li、Liu He、大石高生、鵜殿俊史、重信秀治、柿田明美、那波宏之、Philipp Khaitovich
    • Organizer
      日本進化学会 第17回大会
    • Place of Presentation
      中央大学(東京都、東京)
    • Year and Date
      2015-08-20
    • Related Report
      2015 Research-status Report
  • [Presentation] 霊長類を用いた脳機能研究:人との違いと共通点2015

    • Author(s)
      大石高生
    • Organizer
      第35回日本脳神経外科コングレス総会
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2015-05-08
    • Related Report
      2015 Research-status Report
    • Invited
  • [Book] 脳神経外科医が知っておくべきニューロサイエンスの知識2015

    • Author(s)
      大石高生
    • Total Pages
      2
    • Publisher
      文光堂
    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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