Physiological polymorphism and potential function of atherosclerosis in relation to vascular remodeling.
| Project/Area Number |
15K07243
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied anthropology
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| Research Institution | Nagasaki University |
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Principal Investigator |
SHIMIZU Yuji 長崎大学, 医歯薬学総合研究科(医学系), 客員准教授 (40569068)
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| Co-Investigator(Kenkyū-buntansha) |
永吉 真子 長崎大学, 医歯薬学総合研究科(医学系), 助教 (30728960)
前田 隆浩 長崎大学, 医歯薬学総合研究科(医学系), 教授 (40284674)
門田 耕一郎 長崎大学, 保健・医療推進センター, 助教 (40549458)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | CD34陽性細胞 / 高血圧 / 動脈硬化 / 身長 / 筋力 / 加齢性骨髄機能低下 / 造血幹細胞 / 血管修復 / 血管リモデリング / 骨髄 |
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| Outline of Final Research Achievements |
We collected data of 588 elderly community-dwelling men aged 60-69. Those data suggested that height could act as an indicator of vascular repairing capacity and hematopoiesis. We also found that atherosclerosis could also indicate the activity of microcirculation maintenance which should play an important role in maintenance of muscle strength among elderly hypertensive subjects. Since we reported in previous studies that atherosclerosis could have a beneficial effect for individuals with short stature, specifically stroke prevention, present results partly explain this potential function of atherosclerosis. We also partly showed the physiological polymorphism of vascular remodeling that could be influenced by both "aging decline of bone marrow function" and "hypertension".
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Impact of single nucleotide polymorphism on short stature and reduced tongue pressure among community-dwelling elderly Japanese participants: a cross-sectional study.2017
Author(s)
Shimizu Y, Sato S, Noguchi Y, Koyamatsu J, Yamanashi H, Higashi M, Nagayoshi M, Kadota K, Kawashiri SY, Nagata Y, Takamura N, Maeda T.
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Journal Title
Environ Health Prev Med.
Volume: 22
Issue: 1
Pages: 1-8
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Association between circulating CD34-positive cells and serum alkaline phosphatase in relation to body mass index for elderly Japanese men.2016
Author(s)
Yuji Shimizu, Shimpei Sato, Jun Koyamatsu, Hirotomo Yamanashi, Mako Nagayoshi, Koichiro Kadota, Kazuto Tsuruda, Naomi Hayashida, Norio Abiru, Hironori Yamasaki, Noboru Takamura and Takahiro Maeda.
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Journal Title
Journal of Physiological Anthropology
Volume: 35
Issue: 1
Pages: 2-2
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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