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Physiological polymorphism and potential function of atherosclerosis in relation to vascular remodeling.

Research Project

Project/Area Number 15K07243
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied anthropology
Research InstitutionNagasaki University

Principal Investigator

SHIMIZU Yuji  長崎大学, 医歯薬学総合研究科(医学系), 客員准教授 (40569068)

Co-Investigator(Kenkyū-buntansha) 永吉 真子  長崎大学, 医歯薬学総合研究科(医学系), 助教 (30728960)
前田 隆浩  長崎大学, 医歯薬学総合研究科(医学系), 教授 (40284674)
門田 耕一郎  長崎大学, 保健・医療推進センター, 助教 (40549458)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsCD34陽性細胞 / 高血圧 / 動脈硬化 / 身長 / 筋力 / 加齢性骨髄機能低下 / 造血幹細胞 / 血管修復 / 血管リモデリング / 骨髄
Outline of Final Research Achievements

We collected data of 588 elderly community-dwelling men aged 60-69. Those data suggested that height could act as an indicator of vascular repairing capacity and hematopoiesis. We also found that atherosclerosis could also indicate the activity of microcirculation maintenance which should play an important role in maintenance of muscle strength among elderly hypertensive subjects. Since we reported in previous studies that atherosclerosis could have a beneficial effect for individuals with short stature, specifically stroke prevention, present results partly explain this potential function of atherosclerosis. We also partly showed the physiological polymorphism of vascular remodeling that could be influenced by both "aging decline of bone marrow function" and "hypertension".

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (23 results)

All 2017 2016 2015

All Journal Article (16 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 16 results,  Open Access: 16 results,  Acknowledgement Compliant: 7 results) Presentation (7 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Height is an indicator of vascular maintenance capacity in older men.2017

    • Author(s)
      Shimizu Y, Sato S, Koyamatsu J, Yamanashi H, Nagayoshi M, Kadota K, Maeda T
    • Journal Title

      Geriatr Gerontol Int

      Volume: 印刷中 Issue: 10 Pages: 1-8

    • DOI

      10.1111/ggi.12876

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Platelets and circulating CD34-positive cells as an indicator of the activity of the vicious cycle between hypertension and endothelial dysfunction in elderly Japanese men.2017

    • Author(s)
      Shimizu Y, Sato S, Koyamatsu J, Yamanashi H, Nagayoshi M, Kadota K, Kawashiri S, Inoue K, Nagata Y, Maeda T
    • Journal Title

      Atherosclerosis

      Volume: 259 Pages: 26-31

    • DOI

      10.1016/j.atherosclerosis.2017.02.016

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Possible mechanism underlying the association between higher hemoglobin level and hypertension in older Japanese men.2017

    • Author(s)
      Shimizu Y, Sato S, Koyamatsu J, Yamanashi H, Nagayoshi M, Kadota K, Kawashiri SY, Maeda T.
    • Journal Title

      Geriatr Gerontol Int.

      Volume: 17 Issue: 12 Pages: 2586-2592

    • DOI

      10.1111/ggi.13068

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between high-density lipoprotein-cholesterol and hypertension in relation to circulating CD34-positive cell levels.2017

    • Author(s)
      Shimizu Y, Sato S, Koyamatsu J, Yamanashi H, Nagayoshi M, Kadota K, Kawashiri SY, Maeda T.
    • Journal Title

      J Physiol Anthropol.

      Volume: 36 Issue: 1 Pages: 1-7

    • DOI

      10.1186/s40101-017-0143-9

    • NAID

      120006987415

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum sodium level within the normal range is associated with maximum voluntary tongue pressure against the palate among community-dwelling older Japanese men2017

    • Author(s)
      Shimizu Yuji、Sato Shimpei、Koyamatsu Jun、Yamanashi Hirotomo、Higashi Miho、Nagayoshi Mako、Kadota Koichiro、Kawashiri Shin-Ya、Takamura Noboru、Maeda Takahiro
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 18 Issue: 1 Pages: 183-186

    • DOI

      10.1111/ggi.13152

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Handgrip strength and subclinical carotid atherosclerosis in relation to platelet levels among hypertensive elderly Japanese.2017

    • Author(s)
      Shimizu Y, Sato S, Koyamatsu J, Yamanashi H, Nagayoshi M, Kadota K, Kawashiri SY, Inoue K, Nagata Y, Maeda T.
    • Journal Title

      Oncotarget.

      Volume: 8 Issue: 41 Pages: 69362-69369

    • DOI

      10.18632/oncotarget.20618

    • NAID

      120006987394

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Triglycerides and blood pressure in relation to circulating CD34-positive cell levels among community-dwelling elderly Japanese men: a cross-sectional study.2017

    • Author(s)
      Shimizu Y, Sato S, Noguchi Y, Koyamatsu J, Yamanashi H, Nagayoshi M, Kadota K, Kawashiri SY, Nagata Y, Maeda T.
    • Journal Title

      Environ Health Prev Med.

      Volume: 22 Issue: 1 Pages: 1-7

    • DOI

      10.1186/s12199-017-0684-x

    • NAID

      210000130251

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of single nucleotide polymorphism on short stature and reduced tongue pressure among community-dwelling elderly Japanese participants: a cross-sectional study.2017

    • Author(s)
      Shimizu Y, Sato S, Noguchi Y, Koyamatsu J, Yamanashi H, Higashi M, Nagayoshi M, Kadota K, Kawashiri SY, Nagata Y, Takamura N, Maeda T.
    • Journal Title

      Environ Health Prev Med.

      Volume: 22 Issue: 1 Pages: 1-8

    • DOI

      10.1186/s12199-017-0668-x

    • NAID

      210000130235

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Possible mechanism underlying the association between height and vascular remodeling in elderly Japanese men.2017

    • Author(s)
      Shimizu Y, Sato S, Koyamatsu J, Yamanashi H, Nagayoshi M, Kadota K, Kawashiri SY, Maeda T.
    • Journal Title

      Oncotarget.

      Volume: 9 Issue: 8 Pages: 7749-7757

    • DOI

      10.18632/oncotarget.23660

    • NAID

      120006987297

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of serum gamma-glutamyltransferase (GGT) and diabetes with triglycerides-to-HDL cholesterol ratio in Japanese subjects: The Nagasaki Study2017

    • Author(s)
      Koyamatsu Jun, Shimizu Yuji, Kadota Koichiro, Nagayoshi Mako, Yamanashi Hirotomo, Sato shimpei, Goto Hisashi, Murase Kunihiko, Aoyagi Kiyoshi, Takahiro Maeda
    • Journal Title

      Acta medica Nagasakiensia

      Volume: 61 Pages: 61-65

    • NAID

      130006588812

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Circulating CD34-positive cells are associated with handgrip strength in Japanese older men.2016

    • Author(s)
      Yamanashi H, Shimizu Y, Koyamatsu J, Nagayoshi M, Kadota K, Tamai M, Maeda T
    • Journal Title

      Journal of Frailty and Aging

      Volume: 6 Pages: 6-11

    • DOI

      10.14283/jfa.2016.107

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Platelets as an indicator of vascular repair in elderly Japanese men.2016

    • Author(s)
      Shimizu Y, Sato S, Koyamatsu J, Yamanashi H, Nagayoshi M, Kadota K, Maeda T
    • Journal Title

      Oncotarget

      Volume: 7 Issue: 29 Pages: 44919-44926

    • DOI

      10.18632/oncotarget.10229

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Multiple somatic symptoms and frailty: cross-sectional study in Japanese community-dwelling elderly people.2016

    • Author(s)
      Yamanashi H, Shimizu Y, Koyamatsu J, Nobuyoshi M, Nagayoshi M, Kadota K, Tamai M, Maeda T
    • Journal Title

      Fam Pract

      Volume: 33 Issue: 5 Pages: 453-460

    • DOI

      10.1093/fampra/cmw028

    • NAID

      120006987218

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Association between circulating CD34-positive cells and serum alkaline phosphatase in relation to body mass index for elderly Japanese men.2016

    • Author(s)
      Yuji Shimizu, Shimpei Sato, Jun Koyamatsu, Hirotomo Yamanashi, Mako Nagayoshi, Koichiro Kadota, Kazuto Tsuruda, Naomi Hayashida, Norio Abiru, Hironori Yamasaki, Noboru Takamura and Takahiro Maeda.
    • Journal Title

      Journal of Physiological Anthropology

      Volume: 35 Issue: 1 Pages: 2-2

    • DOI

      10.1186/s40101-016-0084-8

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hemoglobin as a possible biochemical index of hypertension-induced vascular damage2016

    • Author(s)
      Yuji Shimizu, Koichiro Kadota, Mio Nakazato, Yuko Noguchi, Jun Koyamatsu, Hirotomo Yamanashi, Mako Nagayoshi, Shuichi Nagata, Kazuhiko Arima, Takahiro Maeda.
    • Journal Title

      Journal of Physiological Anthropology

      Volume: 35 Issue: 1 Pages: 1-7

    • DOI

      10.1186/s40101-016-0085-7

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Circulating CD34-positive cells, glomerular filtration rate and triglycerides in relation to hypertension.2015

    • Author(s)
      Shimizu Y, Sato S, Koyamatsu J, Yamanashi H, Nagayoshi M, Kadota K, Maeda T
    • Journal Title

      Atherosclerosis

      Volume: 243 Issue: 1 Pages: 71-76

    • DOI

      10.1016/j.atherosclerosis.2015.08.035

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 高齢者における握力低下と血清HDLコレステロールとの関係2017

    • Author(s)
      清水悠路、小屋松淳、永吉真子、山梨啓友、玉井慎美、有馬和彦、青柳潔、前田隆浩
    • Organizer
      第76回日本公衆衛生学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Asian-specific inflammatory single nucleotide polymorphism (SNPs) is associated with height levels among general elderly Japanese.2017

    • Author(s)
      Shimizu Yuji, Koyamatsu Jun, Yamanashi Hirotomo, Nagayoshi Mako, Noguchi Yuko, Kadota Koichiro, Kawashiri Shin-Ya, Arima Kazuhiko, Aoyagi Kiyoshi, Maeda Takahiro.
    • Organizer
      2017 Symposium of the society for the study of human biology & international association of physiological anthropology. Human biology of climate change.
    • Related Report
      2017 Annual Research Report
  • [Presentation] 血管修復指標としての肝細胞増殖因子(HGF)と末梢血CD34陽性細胞2017

    • Author(s)
      清水悠路、小屋松淳、永吉真子、佐藤晋平、山梨啓友、福井翔一、近藤英明、岡田武夫、木山昌彦、前田隆浩
    • Organizer
      第88回日本衛生学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高齢男性における血管リモデリングマーカ-としての白血球数と高血圧2016

    • Author(s)
      清水悠路、佐藤晋平、永吉真子、門田耕一郎、小屋松淳、山梨啓友、有馬和彦、青柳潔、前田隆浩
    • Organizer
      第73回日本生理人類学会
    • Place of Presentation
      大阪市立大学(大阪府・大阪市)
    • Year and Date
      2016-06-04
    • Related Report
      2015 Research-status Report
  • [Presentation] 高齢男性における造血能を考慮した末梢血CD34陽性細胞と中性脂肪との関係2016

    • Author(s)
      清水悠路、小屋松淳、山梨啓友、永吉真子、玉井慎美、有馬和彦、青柳潔、前田隆浩
    • Organizer
      第75回日本公衆衛生学会
    • Place of Presentation
      グランフロント大阪北館、カンファレンスルームタワーC8階05(大阪府、大阪市)
    • Related Report
      2016 Research-status Report
  • [Presentation] 高齢男性における血管リモデリングマーカーとしての白血球と高血圧2016

    • Author(s)
      清水悠路、佐藤晋平、永吉真子、門田耕一郎、小屋松淳、山梨啓友、有馬和彦、青柳潔、前田隆浩
    • Organizer
      第73回日本生理人類学会
    • Place of Presentation
      大阪市立大学学術情報センター10階(大阪府、大阪市)
    • Related Report
      2016 Research-status Report
  • [Presentation] Possible mechanism underlying the positive correlation between hemoglobin and hypertension2016

    • Author(s)
      Shimizu Y, Sato S, Koyamatsu J, Yamanashi H, Nagayohi M, Kadota K, Naeda T.
    • Organizer
      Modernization and Health in the Asia-Pacific Region
    • Place of Presentation
      Imiloa Astronomy Center, Hawai University (USA, Hawai)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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