Comprehensive study on the mechanism of fungal cell-wall glucan synthesis
| Project/Area Number |
15K07352
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
YODA Koji 東京大学, 大学院農学生命科学研究科(農学部), 名誉教授 (20143406)
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| Co-Investigator(Kenkyū-buntansha) |
野田 陽一 東京大学, 大学院農学生命科学研究科(農学部), 助教 (90282699)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 微生物機能 / 酵母細胞壁 / 微生物 |
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| Outline of Final Research Achievements |
Beta-1,6-glucan is an essential cell wall component of the budding yeast, Saccharomyces cerevisiae. However, the details of the beta-1,6-glucan biosynthetic pathway remain largely unknown. We analyzed biochemically the functions of Kre5, Kre6 and Kre9, which have important roles in the beta-1,6-glucan biosynthesis, and obtained findings regarding their functions and protein- protein interactions. These findings will pave the way for the discovery of the new antifungal reagents.
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Report
(4 results)
Research Products
(9 results)
