| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
The growth of fission yeast (S. pombe) CoQ deficient mutants required the addition of cysteine (Cys) or glutathione for antioxidant to the medium, but the affect for gene expression in CoQ deficient mutants have not been elucidated. When the gene expression of the CoQ deficient mutant was analyzed by microarray, the genes of transporter for ion or sulfur compounds were upregulated. The mutant of cysteine synthase gene show the sensitive for hydrogen peroxide and paraquat and the level of reactive oxygen species (ROS) were induced.
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