A novel mechanism for fatty acid transport in mitochondria

• Project/Area Number: 15K07389
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied biochemistry
• Research Institution: Kyoto University
• Principal Investigator: Nagao Kohjiro 京都大学, 工学研究科, 助教 (40587325)
• Co-Investigator(Renkei-kenkyūsha): UMEDA Masato 京都大学, 大学院工学研究科, 教授 (10185069) ; HARA Yuji 京都大学, 大学院工学研究科, 准教授 (60362456)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 脂肪酸 / ミトコンドリア

Outline of Final Research Achievements

We analyzed the mechanism of fatty acid metabolism in Drosophila melanogaster and identified a novel transporter for the fatty acid transport into mitochondria.

Research Products

• [Journal Article] Synthesis of omega-3 long-chain polyunsaturated fatty acid-rich triacylglycerols in an endemic goby, Gymnogobius isaza, from Lake Biwa, Japan. (2018)
  • Author(s): Suito Takuto、Nagao Kohjiro、Hatano Masataka、Kohashi Kenichi、Tanabe Aiko、Ozaki Hiromichi、Kawamoto Jun、Kurihara Tatsuo、Mioka Tetsuo、Tanaka Kazuma、Hara Yuji、Umeda Masato
  • Journal Title: J. B. Volume: in press
  • DOI: 10.1093/jb/mvy035
  • NAID: 40021635152
  • Peer Reviewed
• [Journal Article] An N-terminal di-proline motif is essental for fatty acid-dependent degradation of Δ9-desaturase inDrosophila (2017)
  • Author(s): Murakami Akira、Nagao Kohjiro、Juni Naoto、Hara Yuji、Umeda Masato
  • Journal Title: The Journal of Biological Chemistry Volume: 292 Pages: 19976-19986
  • DOI: 10.1074/jbc.m117.801936
  • Peer Reviewed / Open Access
• [Journal Article] Development of a novel tetravalent synthetic peptide that binds to phosphatidic acid. (2015)
  • Author(s): Rina Ogawa, Kohjiro Nagao, Kentaro Taniuchi, Masaki Tsuchiya, Utako Kato, Yuji Hara, Takehiko Inaba, Toshihide Kobayashi, Yoshihiro Sasaki, Kazunari Akiyoshi, Miho Watanabe-Takahashi, Kiyotaka Nishikawa, Masato Umeda
  • Journal Title: PLoS One. Volume: 10
  • DOI: 10.1371/journal.pone.0131668
  • NAID: 120005756258
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] ABCB4 exports phosphatidylcholine in a sphingomyelin-dependent manner. (2015)
  • Author(s): Zhao, Y., Ishigami, M., Nagao, K., Hanada, K., Kono, N., Arai, H., Matsuo, M., Kioka, N., and Ueda, K.
  • Journal Title: J Lipid Res. Volume: 56 Pages: 644-652
  • DOI: 10.1194/jlr.m056622
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Position 834 in TM6 plays an important role in cholesterol and phosphatidylcholine transport by ABCA1. (2015)
  • Author(s): Shimpei Ito, Kohjiro Nagao, Yasuhisa Kimura, Michinori Matsuo, Noriyuki Kioka, Kazumitsu Ueda
  • Journal Title: Biosci. Biotechnol. Biochem. Volume: 79 Pages: 775-781
  • DOI: 10.1080/09168451.2014.993358
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] ショウジョウバエ細胞の形質膜におけるリン脂質輸送機構の解明 (2016)
  • Author(s): 長尾耕治郎、塩見晃史、梅田真郷
  • Organizer: 日本膜学界「第38回年会」
  • Place of Presentation: 東京(早稲田大学西早稲田キャンパス)
  • Year and Date: 2016-05-10
• [Presentation] ショウジョウバエ細胞の特徴的なリン脂質膜構築機構の解析 (2015)
  • Author(s): 長尾耕治郎, 塩見晃史, 原雄二, 村手源英, 小林俊秀, 梅田真郷
  • Organizer: 第57回日本脂質生化学会
  • Place of Presentation: 東京
  • Year and Date: 2015-05-28