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A novel mechanism for fatty acid transport in mitochondria

Research Project

Project/Area Number 15K07389
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied biochemistry
Research InstitutionKyoto University

Principal Investigator

Nagao Kohjiro  京都大学, 工学研究科, 助教 (40587325)

Co-Investigator(Renkei-kenkyūsha) UMEDA Masato  京都大学, 大学院工学研究科, 教授 (10185069)
HARA Yuji  京都大学, 大学院工学研究科, 准教授 (60362456)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords脂肪酸 / ミトコンドリア
Outline of Final Research Achievements

We analyzed the mechanism of fatty acid metabolism in Drosophila melanogaster and identified a novel transporter for the fatty acid transport into mitochondria.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2018 2017 2016 2015

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (2 results)

  • [Journal Article] Synthesis of omega-3 long-chain polyunsaturated fatty acid-rich triacylglycerols in an endemic goby, Gymnogobius isaza, from Lake Biwa, Japan2018

    • Author(s)
      Suito Takuto、Nagao Kohjiro、Hatano Masataka、Kohashi Kenichi、Tanabe Aiko、Ozaki Hiromichi、Kawamoto Jun、Kurihara Tatsuo、Mioka Tetsuo、Tanaka Kazuma、Hara Yuji、Umeda Masato
    • Journal Title

      The Journal of Biochemistry

      Volume: in press Issue: 2 Pages: 127-140

    • DOI

      10.1093/jb/mvy035

    • NAID

      40021635152

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An N-terminal di-proline motif is essential for fatty acid-dependent degradation of Δ9-desaturase inDrosophila2017

    • Author(s)
      Murakami Akira、Nagao Kohjiro、Juni Naoto、Hara Yuji、Umeda Masato
    • Journal Title

      Journal of Biological Chemistry

      Volume: 292 Issue: 49 Pages: 19976-19986

    • DOI

      10.1074/jbc.m117.801936

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of a Novel Tetravalent Synthetic Peptide That Binds to Phosphatidic Acid.2015

    • Author(s)
      Rina Ogawa, Kohjiro Nagao, Kentaro Taniuchi, Masaki Tsuchiya, Utako Kato, Yuji Hara, Takehiko Inaba, Toshihide Kobayashi, Yoshihiro Sasaki, Kazunari Akiyoshi, Miho Watanabe-Takahashi, Kiyotaka Nishikawa, Masato Umeda
    • Journal Title

      PLOS ONE

      Volume: 10 Issue: 7 Pages: e0131668-e0131668

    • DOI

      10.1371/journal.pone.0131668

    • NAID

      120005756258

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] ABCB4 exports phosphatidylcholine in a sphingomyel-independent manner2015

    • Author(s)
      Zhao, Y., Ishigami, M., Nagao, K., Hanada, K., Kono, N., Arai, H., Matsuo, M., Kioka, N., and Ueda, K.
    • Journal Title

      J. Lipid Res.

      Volume: 56 Issue: 3 Pages: 644

    • DOI

      10.1194/jlr.m056622

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Position 834 in TM6 plays an important role in cholesterol and phosphatidylcholine transport by ABCA12015

    • Author(s)
      Shimpei Ito, Kohjiro Nagao, Yasuhisa Kimura, Michinori Matsuo, Noriyuki Kioka, Kazumitsu Ueda
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 79 Issue: 5 Pages: 775-781

    • DOI

      10.1080/09168451.2014.993358

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] ショウジョウバエ細胞の形質膜におけるリン脂質輸送機構の解明2016

    • Author(s)
      長尾耕治郎、塩見晃史、梅田真郷
    • Organizer
      日本膜学界「第38回年会」
    • Place of Presentation
      東京(早稲田大学西早稲田キャンパス)
    • Year and Date
      2016-05-10
    • Related Report
      2016 Research-status Report
  • [Presentation] ショウジョウバエ細胞の特徴的なリン脂質膜構築機構の解析2015

    • Author(s)
      長尾耕治郎, 塩見晃史, 原雄二, 村手源英, 小林俊秀, 梅田真郷
    • Organizer
      第57回日本脂質生化学会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-28
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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