| Project/Area Number |
15K07408
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bioorganic chemistry
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
FUJII HIROSHI 信州大学, 学術研究院農学系, 教授 (90165340)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 天然物 / 生理活性物質 / カルボニレーション / イソクマリン / ラクトン化 |
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| Outline of Final Research Achievements |
In this study, syntheses of natural products using palladium catalyzed CO insertion and cyclization were performed. As to the synthesis of isocoumarin compounds, syntheses of legioliulin, 8-hydroxy-6-methoxy-3-pentyl-1H-isochromen-1-one, and 6,8-dimethylfusariumin which is analogue fusariumin were accomplished. During this study, concise synthesis of (+)-altholactone was also accomplished. Next, synthetic study of eupaglabric acid which is eudesmane sesquiterpene compound was tried. Allenic triflate was chosen as a precursor of cyclic acylpalladation, however, the reaction gave complex mixture. Thus, the tiflate which possesses terminal double bond was used and it gave desirable compound in 50% yield. The synthesis of eupaglabric acid is currently under way.
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