| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Sialic acids are a family of carbohydrates derived from 3-deoxy-2-ulosonic acid, and more than 50 natural sialic acids have been identified. The most common sialic acid in the human body is N-acetyl neuraminic acid (Neu5Ac), and so research has focused on gangliosides containing Neu5Ac. However, diverse modified sialic acid-containing gangliosides have recently been isolated from echinoderms. Furthermore, the gangliosides showed strong neuritegenic activity toward neuron-like rat adrenal pheochromocytoma (PC12) cells. These findings have stimulated interest in the biological significance of modified sialic acids. Therefore, we aimed to develop methods for synthesizing modified sialic acids to elucidate the molecular basis underlying neurite outgrowth. In this research, the syntheses of gangliosides of echinoderms, which contain modified sialic acids , have been accomplished.
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