Research for new anti-melanoma agents targeting dermcidin
Project/Area Number |
15K07417
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Bioorganic chemistry
|
Research Institution | Kindai University (2017) Kitasato University (2015-2016) |
Principal Investigator |
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
|
Keywords | 抗がん / 海洋微生物 / メラノーマ / dermcidin / 抗がん剤 / スクリーニング |
Outline of Final Research Achievements |
Melanoma cells are thought the worst cancer cells. We researched for finding the melanoma selective anti-cancer agents from the culture broth of marine-derived microorganisms. We screened more than 10,000 culture broths. As a result, we found three new anti-cancer agents. Isomethoxyneihumicin was isolated from the culture broth of marine actinomycete Nocardiopsis alba KM6-1 which had been collected at Chichizima. Chlokamycin was isolated from marine Streptomyces sp. MA2-12. Additionally, one new compound showing strong activity against some melanoma cells was isolated from marine-derived fungus collected at Okinawa.
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Report
(4 results)
Research Products
(9 results)