| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Outline of Final Research Achievements |
Melanoma cells are thought the worst cancer cells. We researched for finding the melanoma selective anti-cancer agents from the culture broth of marine-derived microorganisms. We screened more than 10,000 culture broths. As a result, we found three new anti-cancer agents. Isomethoxyneihumicin was isolated from the culture broth of marine actinomycete Nocardiopsis alba KM6-1 which had been collected at Chichizima. Chlokamycin was isolated from marine Streptomyces sp. MA2-12. Additionally, one new compound showing strong activity against some melanoma cells was isolated from marine-derived fungus collected at Okinawa.
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