| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
A ligand molecule that binds to a target protein is expected to be a useful tool for clarifying a variety of biofunctions. Bioactive natural products have been utilized as a model for designing a novel ligand molecule. In this project, p-terphenyls, steroids, and sugars are selected as the models, and basic studies based on the natural product synthesis were performed. Efficient methods for the syntheses of bioactive p-terphenyls such as polyozellin and kehokorins A-E were developed, thus leading to the structural revision of polyozellin and studies of the structure-activity relationship. Bioassay of newly designed p-terphenyls carrying a biotinyl unit was also examined with the aim of searching the target. For preparation of a ligand molecule utilizing an anticancer steroid as a model, chemical reactions of androsterone were investigated. A novel branched sugar was designed as a glycosidase inhibitor and was synthesized from D-glucose.
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