Chemical studies of oolong tea polyphenol and molecular mechanism of its bioactivity
| Project/Area Number |
15K07427
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Gifu University |
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Principal Investigator |
YANASE Emiko 岐阜大学, 応用生物科学部, 准教授 (60313912)
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| Co-Investigator(Kenkyū-buntansha) |
長岡 利 岐阜大学, 応用生物科学部, 教授 (50202221)
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| Research Collaborator |
NAGAOKA Satoshi 岐阜大学, 応用生物科学部, 教授 (50202221)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | Polymeric polyphenol / Oolong tea / Catechin / Oxidaiton / Oolomgtheanin / ウーロン茶ポリフェノール / カテキン / ウーロンテアニン / 酸化 / コレステロール / 烏龍茶ポリフェノール / コレステロールミセル溶解性 / タウロコール酸 |
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| Outline of Final Research Achievements |
We thought the dimeric catechin is one of the important intermediates of polymeric polyphenol generation from catechin, and to clarify the chemical structure of polymeric polyphenol, the oxidation of oolongtheanin were investigated. New intramolecular bond was formed by the oxidation of oolongtheanin, no polymerization reaction was caused. Oxidation of oolongtheanin was performed with coexistence of catechin. However, because reactivity of catechin is higher than oolongtheanin under oxidative condition, oxidation products from catechin were only produced. These result suggests that the known dimeric catechin such as oolongtheanin were not so much key intermediate of polymeric polyphenol formation but byproduct.
In order to clarify the decreasing mechanism of the micellar solubility of cholesterol, we investigated the interaction between tea polyphenols and cholesterol micelles. The data indicated a regiospecifically interaction of EGCg with taurocholic acid.
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Report
(4 results)
Research Products
(11 results)
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[Presentation] Oxidation of Epicatechin2016
Author(s)
Kazuhiro Ucida, Kazuki Ogawa, Emiko Yanase
Organizer
the international Symposium on Natural Products for the Future 2016
Place of Presentation
Tokushima Bunri University
Year and Date
2016-09-01
Related Report
Int'l Joint Research
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