| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Balance of intestinal gut microflora is deeply related to the host health and onset of various diseases. Thus formation of eligible gut flora will lead to prophylaxis of infections and metabolic syndromes. However, studies are still insufficient about endogenous promoting factors for establishing eligible gut flora. Lactoferrin (LF) widely prevents growth of pathogens from bacteria to fungi while it promotes growth of Bifidobacterium. Our group previously reported intracellular fragmentation of endocytosed LF in cultured intestinal epithelial cells and subsequent release to the outside. In this study we will analyze the degradation and release process of LF, and evaluate the functions of LF fragments in establishment of gut flora and physiology.
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