| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Mucosal injury in gastrointestinal (GI) tract is frequently observed in chronic user of non-steroidal anti-inflammatory drugs (NSAIDs). Here, we developed a functional food for prevention of NSAIDs-induced stomach ulcer based on a biological action of lysophosphatidic acid (LPA). We found that concentration of LPA in stomach fluid is 2-3 microM, and that LPA around the physiological concentration enhances production of PGE2 and proliferation of stomach cells. Among examined, brans of rice and buckwheat, roots of Syakuyaku herb were found to contain abundant LPA and PA, a precursor of LPA. The lipid extracts from these plant materials prevented aspirin- or indomethacin-induced stomach ulcer in mice. It will be possible to develop functional foods for prevention of side effect of NSAIDs using these LPA- or PA-rich plant materials.
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