Chemical and biological studies on the various functions of propolis
| Project/Area Number |
15K07436
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | University of Shizuoka |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中村 純 玉川大学, 農学部, 教授 (30256002)
細谷 孝博 横浜薬科大学, 薬学部, 講師 (30506572)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | プロポリス / ミツバチ / ブラジル / アルテピリンC / ニムフェオールC / セネガル / アルテピリンＣ / インドネシア / タイ / スチルベン / ハワイ / 抗菌性 |
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| Outline of Final Research Achievements |
Propolis is a natural resinous substance collected by honeybees from buds and exudates of certain trees and plants to protect their beehive from enemies. It is used as folk medicine in many regions of the world and has been reported to display various biological activities. In this study, chemical and biological methods were applied to evaluate the functions of propolis. In particular, chemical analyses of the propolis from tropic and sub tropic areas such as Senegal, Indonesia and Thailand were carried out. We identified several stilbene compounds from Senegalese propolis. Further the anti-inflammatory potency of Senegalese propolis was higher than that of other propolis that had been previously reported. On the other hand, we clarified that artepillin C from Brazilian propolis induces brown-like adipocyte formation and nymphaeol-C suppresses the expression of fibroblast growth factor 18.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Artepillin C, a typical Brazilian propolis-derived component, induces brown-like adipocyte formation in C3H10Ｔ1/2 cells, primary inguinal white adipose tissue-derived adipocytes, and mice.2016
Author(s)
Nishikawa, S., Aoyama, H., Kamiya, M., Higuchi, J., Kato, A., Soga, M., Kawai, T., Yoshimura, K., Kumazawa, S., Tsuda, T.
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Journal Title
PLoS ONE
Volume: 11
Issue: 9
Pages: e0162512-e0162512
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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