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Function of acetic acid on the prevention in dysfuntion of ageing skeletal muscle

Research Project

Project/Area Number 15K07437
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Food science
Research InstitutionOkayama Prefectural University

Principal Investigator

Yamashita Hiromi  岡山県立大学, 保健福祉学部, 教授 (70254563)

Co-Investigator(Renkei-kenkyūsha) KIMOTO Masumi  岡山県立大学, 保健福祉学部, 教授 (40108866)
Research Collaborator ABE Reina  
IWATA Miyuki  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords酢酸 / 骨格筋 / L-6筋管細胞 / 脂肪代謝 / 高齢動物 / 筋管細胞 / 遅筋線維 / ミトコンドリア
Outline of Final Research Achievements

In this study, we examined the activation of AMPK and the stimulation of GLUT4 and myoglobin expression by acetic acid in skeletal muscle cells to clarify the physiological function of acetic acid in skeletal muscle cells. Acetic acid added to culture medium was taken up rapidly by L6 cells, and AMPK was phosphorylated upon treatment with acetic acid. We observed increased gene and protein expression of GLUT4 and myoglobin. Furthermore, treated cells also showed increased gene and protein expression of myocyte enhancer factor 2A (MEF2A), which is a well-known transcription factor involved in the expression of myoglobin and GLUT4 genes.
These results indicate that acetic acid enhances glucose uptake and fatty acid metabolism through the activation of AMPK, and increases expression of GLUT4 and myoglobin. In addition, this study presented that the treatment of acetic acid would increase expression of PGC1a that involves with mitochondrial generation in skeletal muscle cells.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (37 results)

All 2018 2017 2016 2015

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 6 results,  Acknowledgement Compliant: 4 results) Presentation (27 results) (of which Int'l Joint Research: 11 results,  Invited: 6 results) Book (4 results)

  • [Journal Article] Effect of exercise training with intake of acetic acid on lipid metabolism and endurance performance = 酢酸摂取と運動が脂肪代謝と運動耐久性に及ぼす影響2017

    • Author(s)
      Aya Araki, Yukihiro Yoshimura, Yumiko Yamaguchi, Hitomi Maruta, Masumi Kimoto, Yoshitaka Takahashi, Hiromi Yamashita
    • Journal Title

      岡山県立大学保健福祉学部紀要

      Volume: 23 Pages: 21-32

    • DOI

      10.15009/00001966

    • NAID

      120006010000

    • URL

      https://oka-pu.repo.nii.ac.jp/records/1985

    • Year and Date
      2017-03-12
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Molecular Cloning of Rat acss3 and Characterization of Mammalian Propionyl-CoA Synthetase in the Liver Mitochondrial Matrix2017

    • Author(s)
      Y. Yoshimura, A. Araki, H. Maruta, Y. Takahashi, and H. Yamashita
    • Journal Title

      Journal of Bochemistry

      Volume: 161 Pages: 279-289

    • DOI

      10.1093/jb/mvw067

    • NAID

      40021162084

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Nutritional Composition and Physical Properties of OPU-Rice-Noodle2016

    • Author(s)
      2.吉村征浩、江木智恵美、北川昌昭、奥島信行、我如古菜月、新田陽子、岸本妙子、中島伸佳、久保田恵、伊東秀之、山下広美、辻英明
    • Journal Title

      岡山県立大学保健福祉学部紀要

      Volume: 22 Pages: 57-64

    • DOI

      10.15009/00001298

    • NAID

      120005714087

    • URL

      https://oka-pu.repo.nii.ac.jp/records/1313

    • Year and Date
      2016-03-12
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Changes in the 5’-AMP concentration of skeletal muscles on acetic acid treatment under fed or starved conditions in rats2016

    • Author(s)
      Araki A, Yoshimura Y, Maruta H, Kimoto M, Takahashi Y and Yamashita H
    • Journal Title

      Annals of Obesity & Disorders

      Volume: 1 Pages: 1-3

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Activation of AMP-Activated Protein Kinase and Stimulation of Energy Metabolism by Acetic Acid in L6 Myotube Cells.2016

    • Author(s)
      H. Maruta, Y. Yoshimura, A. Araki, M. Kimoto, Y. Takahashi, and H. Yamashita
    • Journal Title

      PLos One

      Volume: 11 Issue: 6 Pages: 1-19

    • DOI

      10.1371/journal.pone.0158055

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Biological function of acetic acid -Improvement of obesity and glucose tolerance by acetic acid in type 2 diabetic rats2016

    • Author(s)
      Hiromi Yamashita
    • Journal Title

      Critical Reviews in Food Science and Nutrition

      Volume: 56 Issue: sup1 Pages: 1-5

    • DOI

      10.1080/10408398.2015.1045966

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 酢酸の骨格筋における生理機能に関する研究2018

    • Author(s)
      丸田ひとみ、吉村征浩、荒木彩、礒野千晶、山下広美
    • Organizer
      おかやまバイオアクティブ研究会第52回シンポジウム 第18回学生プレゼンテーション・ポスターセッション
    • Related Report
      2017 Annual Research Report
  • [Presentation] 加齢に伴う骨格筋の萎縮および生活習慣病の発症を予防する機能性食品に関する研究2018

    • Author(s)
      山下広美、丸田ひとみ、吉村征浩、礒野千晶、川上貴代、入江康至、綾部誠也
    • Organizer
      KMSメディカル・アーク2018
    • Related Report
      2017 Annual Research Report
  • [Presentation] 2型糖尿病モデル動物を用いたビフィズス菌発酵乳の肥満抑制効果2018

    • Author(s)
      丸田ひとみ、王承鐸、天満晴菜、馬芸、中村昇二、藤井祐介、豊川直樹、山下広美
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] お酢のチラカを学ぶ2018

    • Author(s)
      山下広美
    • Organizer
      ライフパーク倉敷市民学習講座
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 加齢に伴うラット骨格筋における生化学的変化に関する研究2017

    • Author(s)
      丸田ひとみ、吉村征浩、荒木彩、高橋吉孝、山下広美
    • Organizer
      第71回日本栄養・食糧学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 瀬戸内海沿岸海域で養殖されたマガキの脂肪酸および遊離アミノ酸含有量の季節変動2017

    • Author(s)
      礒野千晶、近藤千尋、柾岡沙梨、丸田ひとみ、吉村征浩、伊東佳邦、花田恭孝、平澤久紀、三宅剛史、山下広美
    • Organizer
      第71回日本栄養・食糧学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 酢酸摂取がラットの腸内細菌叢構成に与える影響2017

    • Author(s)
      吉村征浩、岩田三有紀、丸田ひとみ、山下広美
    • Organizer
      第71回日本栄養・食糧学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] マガキ含有成分の機能性に関する研究2017

    • Author(s)
      礒野千晶、寺尾美貴、丸田ひとみ、三宅剛史、山下広美
    • Organizer
      第50回日本栄養・食糧学会中国四国支部大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 酢酸の生理機能性を軸にしたこれまでの研究と栄養学分野での教育活動2017

    • Author(s)
      山下広美
    • Organizer
      第6回日本栄養学教育学会学術総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 骨格筋に及ぼす酢酸の継続的な摂取の影響についての検討2016

    • Author(s)
      丸田ひとみ、阿部怜奈、荒岡千尋、吉村征浩、木本眞順美、高橋吉孝、山下広美
    • Organizer
      第70回日本栄養・食糧学会大会
    • Place of Presentation
      武庫川女子大学(西宮市)
    • Related Report
      2016 Research-status Report
  • [Presentation] 瀬戸内海の3つの地域で養殖されたマガキ含有成分の季節変動および養殖地域による違い瀬戸内海の3つの地域で養殖されたマガキ含有成分の季節変動および養殖地域による違い2016

    • Author(s)
      礒野千晶、近藤千尋、柾岡、吉村征浩、花田、伊東佳邦、平澤、山下広美
    • Organizer
      (一社)日本家政学会第68回大会
    • Place of Presentation
      金城学院大学(名古屋市)
    • Related Report
      2016 Research-status Report
  • [Presentation] 酢酸摂取が腸内細菌叢組成に与える影響に関する研究2016

    • Author(s)
      岩田三有紀、丸田ひとみ、吉村征浩、田中晃一、入江康至、山下広美
    • Organizer
      第49回日本栄養・食糧学会 中国・四国支部大会
    • Place of Presentation
      徳島大学(徳島市)
    • Related Report
      2016 Research-status Report
  • [Presentation] Activation of AMP-activated Protein Kinase and Stimulation of Energy Metabolism by Acetic Acid in L6 Myotube Cells2016

    • Author(s)
      Hitomi Maruta, Yukihiro Yoshimura, Aya Araki, Masumi Kimoto, Yoshitaka Takahashi, Hiromi Yamashita
    • Organizer
      The 10th Joint Conference on Nutrition between Nanchang, Okayama Prefectural, Sichuan and Woosong Universities
    • Place of Presentation
      Woosong University(Korea)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Seasonal variations and regional differences in major components of oyster from Seto Inland Sea2016

    • Author(s)
      Chiaki Isono, Sari Masaoka, Chihiro Kondo, Ryota Hishimo, Hitomi Maruta, Yukihiro Yoshimura, Yasutaka Hanada, Yoshikuni Ito, Hisanori Hirasawa, Hiromi Yamashita
    • Organizer
      The 10th Joint Conference on Nutrition between Nanchang, Okayama Prefectural, Sichuan and Woosong Universities
    • Place of Presentation
      Woosong University(Korea)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects of Acetic Acid on Composition of Gut Microbiota in Rat2016

    • Author(s)
      Miyuki Iwata, Hitomi Maruta, Yukihiro Yoshimura, Koichi Tanaka, Yasuyuki Irie, Yoshitaka Takahashi, Hiromi Yamashita
    • Organizer
      The 10th Joint Conference on Nutrition between Nanchang, Okayama Prefectural, Sichuan and Woosong Universities
    • Place of Presentation
      Woosong University(Korea)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 酢酸の代謝とメタボリックシンドローム予防効果2016

    • Author(s)
      山下広美
    • Organizer
      栄養改善学会四国支部会
    • Place of Presentation
      四国大学(徳島市)
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Activation of AMP-activated protein kinase and stimulation of energy metabolism by the treatment of acetic acid in L6 myotube cells2015

    • Author(s)
      Hitomi Maruta, Yukihiro Yoshimura, Aya Araki, Masumi Kimoto, Yoshitaka Takahashi, and Hiromi Yamashita
    • Organizer
      8th International Conference on Cachexia, Sarcopenia and Muscle Wasting
    • Place of Presentation
      Paris (France)
    • Year and Date
      2015-12-04
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 骨格筋における酢酸摂取後のAMP濃度の違いは生理状態に依存する2015

    • Author(s)
      荒木彩、守上奈央子、吉村征浩、木本眞順美、山下広美
    • Organizer
      第48回日本栄養・食糧学会中国四国支部大会
    • Place of Presentation
      広島女学院大学(広島市)
    • Year and Date
      2015-10-31
    • Related Report
      2015 Research-status Report
  • [Presentation] 生活の中で生かす機能性食品、食酢の機能と健康-酢酸のメタボリックシンドローム予防効果-2015

    • Author(s)
      山下広美
    • Organizer
      第48回日本栄養・食糧学会中国四国支部大会 市民公開講座
    • Place of Presentation
      メルバルク広島(広島市)
    • Year and Date
      2015-10-31
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 醸造酢の主成分である酢酸の機能性について-肥満と生活習慣病の予防の観点から-2015

    • Author(s)
      山下広美
    • Organizer
      健康食品管理士会中国支部研修会・市民公開講座
    • Place of Presentation
      岡山大学鹿田キャンパス(岡山市)
    • Year and Date
      2015-07-04
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Improvement of obesity and glucose tolerance by acetate in type 2 diabetic rats2015

    • Author(s)
      Hiromi Yamashita
    • Organizer
      International Symposium on Phytochemicals in Medicine and Food(ISPMF2015)
    • Place of Presentation
      Shanghai Normal University, Shanghai, China
    • Year and Date
      2015-06-26
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Effects of chronic intake of acetate on muscle fiber type and endurance performance2015

    • Author(s)
      Hiromi Yamashita, Chihiro Araoka, Yukihiro Yoshimura, Aya Araki, Masumi Kimoto
    • Organizer
      12th Asian Congress of Nutrition
    • Place of Presentation
      Pacifico Yokohama(Yokohama)
    • Year and Date
      2015-05-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Acetic acid increases adenosine monophosphate level and phosphorylation of AMP-activated protein kinase in skeletal muscles2015

    • Author(s)
      Aya Araki, Yukihiro Yoshimura, Masumi Kimoto, Hiromi Yamashita
    • Organizer
      12th Asian Congress of Nutrition
    • Place of Presentation
      Pacifico Yokohama(Yokohama)
    • Year and Date
      2015-05-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Metabolism of exogenous acetic acid induces glut4 expression through activation of AMP-activated protein kinase in rat L6 myotube cells2015

    • Author(s)
      Yukihiro Yoshimura, Hitomi Maruta, Aya Araki, Masumi Kimoto, Yoshitaka Takahashi, Hiromi Yamashita
    • Organizer
      12th Asian Congress of Nutrition
    • Place of Presentation
      Pacifico Yokohama(Yokohama)
    • Year and Date
      2015-05-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Physiological Significance of The Metabolic Pathways for Methylated Arginines in Rat Brain2015

    • Author(s)
      Yamamoto S, Suzuki-Yamamoto T, Ito A, Kaminoura S, Kawakami Y, Yamashita H, Hatakenaka H, Takahashi Y, Kimoto M
    • Organizer
      12th Asian Congress of Nutrition
    • Place of Presentation
      Pacifico Yokohama(Yokohama)
    • Year and Date
      2015-05-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Inhibitory effect of nutmeg extracts on 5-lipoxygenase activity2015

    • Author(s)
      Yuki Kawakami, Yoshiko Mori, Kensuke Okamoto, Shuji Okochi, Toshiko Suzuki-Yamamoto, Masumi Kimoto, Hiromi Yamashita, Hideyuki Ito, Yoshitaka Takahashi
    • Organizer
      12th Asian Congress of Nutrition
    • Place of Presentation
      Pacifico Yokohama(Yokohama)
    • Year and Date
      2015-05-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Inhibition of leukocyte-type 12-lipoxygenase activity by Chinese tea2015

    • Author(s)
      Yoshiko Mori, Akemi Otsuki, Shuji Okochi, Kensuke Okamoto, Yuki Kawakami, Toshiko Suzuki-Yamamoto, Hiromi Yamashita, Masumi Kimoto, Hideaki Tsuji, Hideyuki Ito, Ding Zhi Fang, Yoshitaka Takahashi
    • Organizer
      12th Asian Congress of Nutrition
    • Place of Presentation
      Pacifico Yokohama(Yokohama)
    • Year and Date
      2015-05-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Book] 食べ物と健康 食品の科学(改訂第2版)2018

    • Author(s)
      山下広美 他
    • Total Pages
      331
    • Publisher
      南江堂
    • ISBN
      9784524251582
    • Related Report
      2017 Annual Research Report
  • [Book] 分子栄養学2018

    • Author(s)
      山下広美 他
    • Total Pages
      223
    • Publisher
      講談社
    • ISBN
      9784061553972
    • Related Report
      2017 Annual Research Report
  • [Book] 食品学 : 食べ物と健康2017

    • Author(s)
      山下広美 他
    • Total Pages
      211
    • Publisher
      講談社
    • ISBN
      9784061553392
    • Related Report
      2017 Annual Research Report
  • [Book] 食品の科学2015

    • Author(s)
      山下広美 他
    • Total Pages
      285
    • Publisher
      南江堂
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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