| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Anatomical containment of commensal bacteria in the intestinal mucosa is promoted by innate lymphoid cells (ILCs). We show that Peyer’s patch (PP) ILCs robustly produce IL-22 in the absence of exogenous stimuli. In vivo depletion of ILCs rather than T cells altered the composition of and allowed the proliferation of bacteria in PPs. Collectively, our results show that ILCs restrain commensal bacteria in the PPs.
Intestinal immunoglobulins (Igs) protect against microbes. We have investigated the roles of APRIL (TNFSF13) and BAFF (TNFSF13B) in intestinal Ig induction. PPs are, at least in part, an inductive site for Igs, including IgA. Our results demonstrate that APRIL and BAFF in vivo lowered the frequency of isotype-switched B cells in PPs. These results indicate that APRIL and BAFF paradoxically downregulate homeostatic Ig production in the intestines.
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