| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Mechanisms for sex differences in intestinal absorption of vitamin E (α-tocopherol) were investigated with rats. First, we investigated fecal α-tocopherol excretion in male and female rats, castrated male rats and testosterone administered rats, and clarified that testosterone reduces α-tocopherol absorption. Next, Niemann-Pick C1-Like 1 (NPC1L1) activity was not demonstrated to be a cause for the sex difference of α-tocopherol absorption with rats administered with NPC1L1 inhibitor. Finally, we found that intestinal scavenger receptor class B type 1 (SR-BI) level was higher in females than in males and decreased by castration. From these results, we conclude that testosterone reduces intestinal SR-BI and α-tocopherol absorption, resulting in lower vitamin E concentration in male rats than female rats.
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