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Synthesis of bio-active products by autoxidation of tree components

Research Project

Project/Area Number 15K07503
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Wood science
Research InstitutionYamagata University

Principal Investigator

ASHITANI Tatsuya  山形大学, 農学部, 教授 (20423486)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsテルペノイド / 自働酸化 / ヤマトシロアリ / 木材腐朽菌 / 生理活性物質 / 樹木未利用成分 / セスキテルペン / ジテルペン / 自動酸化 / 抗蟻活性 / 抗菌活性 / ツヨプセン / ロンギホレン / 抗議活性
Outline of Final Research Achievements

Autoxidation of terpenoids, for example carophyllene, longifolene, thujopsene, and cembrene etc., was investigated to test the bio-activities of the reaction products. New autoxidation products were obtained from terpenoid autoxidation heated at 100-120 oC. Especially, as new knowledges for autoxidation mechanism, it was indicated that longifolene was converted into the autoxidation products via the formation of longifolene oxide as an intermediate. The bio-activities of the autoxidation products were tested on anti-termite anti-fungal, anti-algae activity and/or plant growth inhibitory activity. Most of autoxidation products had stronger activities for target organisms than original terpenoid before autoxidation. The bio-active products were obtained at a higher yield in the heating reaction than reaction at room temperature.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (8 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (5 results) (of which Int'l Joint Research: 2 results)

  • [Int'l Joint Research] 王立工科大学/ストックホルム大学(スウェーデン)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Natural autoxidation of longifolene and anti-termite activities of the products2017

    • Author(s)
      Mukai Akisato、Takahashi Koetsu、Ashitani Tatsuya
    • Journal Title

      Journal of Wood Science

      Volume: 63 Issue: 4 Pages: 360-368

    • DOI

      10.1007/s10086-017-1637-0

    • NAID

      40021280368

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antifungal activity of longifolene and its autoxidation products2017

    • Author(s)
      Mukai Akisato、Takahashi Koetsu、Ashitani Tatsuya
    • Journal Title

      European Journal of Wood and Wood Products

      Volume: 76 Issue: 3 Pages: 1079-1082

    • DOI

      10.1007/s00107-017-1281-9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] Thujopseneの過熱による自動酸化生成物の抗菌活性2018

    • Author(s)
      向井堯徳,高橋孝悦,芦谷竜矢
    • Organizer
      第68回日本木材学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Thujopsene の加熱による自動酸化生成物の抗蟻活性2017

    • Author(s)
      向井 尭徳、高橋 孝悦、芦谷 竜矢
    • Organizer
      第67回日本木材学会大会
    • Place of Presentation
      アクロス福岡(福岡市)
    • Year and Date
      2017-03-18
    • Related Report
      2016 Research-status Report
  • [Presentation] Inhibition activity of components in Japanese conifer against invasive plant species2017

    • Author(s)
      Tatsuhiko Yokosuka, Shunya Tanaka, Koetsu Takahashi, Tatsuya Ashitani
    • Organizer
      The joint meeting of 33rd annual meeting of the ISCE and the 9th meeting of APACE
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Thujopseneの自動酸化反応2016

    • Author(s)
      向井尭徳,高橋孝悦,芦谷竜矢
    • Organizer
      第66回日本木材学会大会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2016-03-28
    • Related Report
      2015 Research-status Report
  • [Presentation] Autoxidation of longifolene and antitermite activity of its products2015

    • Author(s)
      Akisato Mukai, Tatsuya Ashitani, Koetsu Takahashi
    • Organizer
      2015 International Chemical Congress of Pacific Basin Societies (Pacifichem 2015)
    • Place of Presentation
      米国,ハワイ州
    • Year and Date
      2015-12-19
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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