| Project/Area Number |
15K07585
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Aquatic life science
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| Research Institution | Kitasato University |
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Principal Investigator |
Nakamura Osamu 北里大学, 海洋生命科学部, 准教授 (00306648)
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| Research Collaborator |
Tsutsui Shigeyuki 北里大学, 海洋生命科学部, 准教授 (20406911)
Takimoto Miki 北里大学, 大学院海洋生命科学研究科
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | マダイ / 脂肪組織 / 白血球 / 炎症性サイトカイン / Vibrio anguillarum |
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| Outline of Final Research Achievements |
Abdominal adipose tissue (AAT) is an active immune organ that harbors a number of leukocytes, especially macrophages in mammal. To elucidate properties of AAT of red sea bream Pagrus major as an immune organ, I performed differential count of AAT-resident leukocytes. I also analyzed expression of the genes of some proinflammatory cytokines in AAT after intraperitoneal injection of formalin-killed Vibrio anguillarum. I found that a number of leukocytes, especially eosinophilic granulocytes are present in the AAT of P. major. After injection of V. anguillarum, significant up-regulation of gene expression of some proinflammatory cytokines was demonstrated by quantitative PCR. These result indicate that AAT of P. major is an active immune organ that can evoke inflammatory responses.
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