| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Aeromonas hydrophila requires iron for its survival and growth. Ferric iron is transported into A. hydrophila by a number of chelating compounds called siderophores. Iron transport through the outer membrane receptor protein by amonabactin, ferrioxamine B, enterobactin, ferrichrome, and heme was catalyzed by highly specific proteins and across the cytoplasmic membrane by ABC transport systems with lower specificity. Transcription of the transport protein genes was regulated by the Fur protein, which when loaded with ferrous iron functions as a repressor. The purified outer membrane protein could protect goldfish Carassius auratus against A. hydrophila infection. Therefore, these data suggest that the protein could be selected as potential candidate for vaccine development.
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