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Study on fetal nutritional environment related to future lactation and reproduction and its improvement in dairy cattle.

Research Project

Project/Area Number 15K07684
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Animal production science
Research InstitutionObihiro University of Agriculture and Veterinary Medicine

Principal Investigator

KUNITOMO (KAWASHIMA) Chiho  帯広畜産大学, 畜産学部, 准教授 (20374770)

Co-Investigator(Kenkyū-buntansha) 松井 基純  帯広畜産大学, 畜産学部, 教授 (20374762)
清水 隆  帯広畜産大学, 畜産学部, 准教授 (90375113)
木田 克弥  帯広畜産大学, 畜産学部, 教授 (70419216)
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords乳牛 / 妊娠 / 胎子 / 栄養代謝 / インスリン抵抗性 / 発育 / 春機発動 / 卵巣 / 妊娠末期 / 子牛 / 成長 / 繁殖 / インスリン感受性
Outline of Final Research Achievements

The aim of the present study was to investigate the effects of the fetal nutritional environment (= metabolic status of mother cow during the late pregnancy) on their future milk production and reproductive performance. In addition, we investigated the effect of supplementation to improve metabolic status of mother cow during the late pregnancy. Some indicators of insulin resistance (diabetes) used in humans could be useful for evaluation of metabolic status of mother cows during the late pregnancy. In addition, calves from mother cows with strong insulin resistance (poor metabolic state) had lower body weight at birth and easy to get fat. Moreover, glycerol supplementation for enhancement of energy status from 3 weeks before expected calving date to calving improved energy status of mother cows, but no effect on body weight at birth and metabolic status of their calves.

Academic Significance and Societal Importance of the Research Achievements

乳牛の妊娠期は泌乳期と乾乳期を跨いでおり、泌乳期では生産性を重視した飼育管理、乾乳期では分娩時の事故や分娩後の疾病予防、乳生産などを重視した飼育管理が行われているが、将来の後継牛となる産子の栄養代謝状態までは考慮されていない。このような中、本研究の成果は、乳牛の妊娠期の栄養代謝状態を胎子環境と捉えて飼育管理することの重要性を明らかにし、まだ一例ではあるが、乳牛の妊娠期の栄養代謝状態悪化を軽減するための方法を提案した。本研究の成果も含め、今後さらなる研究が進むことで将来の乳生産や繁殖性につながる飼育管理が胎子期から可能になり、根本的に健全な乳牛を飼育する方法の構築に貢献できるといえる。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (17 results)

All 2018 2017 2016

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (12 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Relationship of vaginal discharge characteristics evaluated by Metricheck device to metabolic status in postpartum dairy cows2018

    • Author(s)
      Kawashima Chiho、Suwanai Masashi、Honda Toshihiko、Teramura Makoto、Kida Katsuya、Hanada Masaaki、Miyamoto Akio、Matsui Motozumi
    • Journal Title

      Reproduction in Domestic Animals

      Volume: 53 Issue: 6 Pages: 1396-1404

    • DOI

      10.1111/rda.13255

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of rumen fill score and energy status during the close-up dry period with conception at first artificial insemination in dairy cows.2016

    • Author(s)
      Kawashima C, Karaki C, Munakata M, Matsui M, Shimizu T, Miyamoto A, Kida K.
    • Journal Title

      Anim. Sci. J.

      Volume: 87(10) Issue: 10 Pages: 1218-1224

    • DOI

      10.1111/asj.12555

    • NAID

      120006390962

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Polymorphism in promoter region of growth hormone receptor is associated with potential production capacity of insulin-like growth factor-1 in pre-pubertal Holstein.2016

    • Author(s)
      Kawashima C, Munakata M, Matsui M, Miyamoto A, Kida K, Shimizu T.
    • Journal Title

      J. Anim. Physiol. Anim. Nutr.

      Volume: 100(6) Issue: 6 Pages: 1037-1040

    • DOI

      10.1111/jpn.12470

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Relationship between the degree of insulin resistance during late gestation and postpartum performance in dairy cows and factors that affect growth and metabolic status of their calves2016

    • Author(s)
      Kawashima C, Munakata M, Shimizu T, Miyamoto A, Kida K, Matsui M.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 78 Issue: 5 Pages: 739-745

    • DOI

      10.1292/jvms.15-0583

    • NAID

      130005154281

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influence of hepatic load from far-off dry period to early postpartum period on the first postpartum ovulation and accompanying subsequent fertility in dairy cows2016

    • Author(s)
      Kawashima C, Ito N, Nagashima S, Matsui M, Sawada K, Schweigert FJ, Miyamoto A, Kida K.
    • Journal Title

      Journal of Reproduction and Development

      Volume: 62 Issue: 3 Pages: 289-295

    • DOI

      10.1262/jrd.2015-141

    • NAID

      130005157172

    • ISSN
      0916-8818, 1348-4400
    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 乳用牛における妊娠末期のグリセリン給与が栄養代謝状態に及ぼす影響2018

    • Author(s)
      長谷川類、近藤萌里、澁谷俊樹、杉本優香、山岸則夫、川島千帆
    • Organizer
      北海道畜産草地学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 乾乳牛へのグリセリンペレット給与による 分娩後の疾病発生予防ならびに繁殖機能回復への効果2018

    • Author(s)
      近藤萌里・長谷川類・畔上正晴・大井樹里・川島千帆
    • Organizer
      北海道畜産草地学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 乳用育成雌牛における春機発動前後の卵巣動態とその開始時期に及ぼす要因2018

    • Author(s)
      川島千帆・近藤萌里・田代真衣子
    • Organizer
      日本繁殖生物学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 乳用牛の産子に影響を及ぼす妊娠末期のインスリン抵抗性の評価方法の検討2018

    • Author(s)
      長谷川類、岩瀬いづみ、髙木智弘、近藤萌里、松井基純、川島千帆
    • Organizer
      日本繁殖生物学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 乳牛における分娩前のルーメンフィルスコアと分娩前後の 栄養代謝状態ならびに分娩後の疾病発生と繁殖機能回復との関係2018

    • Author(s)
      近藤萌里・長谷川類・加藤葉月・福嶋知賀子・川島千帆
    • Organizer
      日本繁殖生物学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 乳牛における分娩前のルーメンフィルスコアと分娩前後の 栄養代謝状態ならびに分娩後の疾病発生との関連2018

    • Author(s)
      近藤萌里・長谷川類・加藤葉月・福嶋知賀子・川島千帆
    • Organizer
      日本畜産学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 乳用牛における妊娠末期のインスリン抵抗性と採食制御ホルモンとの関連2018

    • Author(s)
      長谷川類・岩瀬いづみ・髙木智弘・川島千帆
    • Organizer
      日本畜産学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 乳用牛における妊娠末期のインスリン抵抗性と産子の栄養代謝状態および発育との関係2018

    • Author(s)
      川島千帆・長谷川類・岩瀬いづみ・髙木智弘・近藤萌里・清水隆・松井基純
    • Organizer
      日本畜産学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 乳牛における分娩前のルーメンフィルスコアと分娩前後の 栄養代謝状態ならびに分娩後の疾病発生との関連性2017

    • Author(s)
      近藤萌里・加藤葉月・岩瀬いづみ・川島千帆
    • Organizer
      北海道畜産草地学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Insulin resistance during late gestation in Holstein cows is related to their calf metabolism rather than postpartum fertility2017

    • Author(s)
      Chiho Kawashima, Izumi Iwase, Moeri Kondo, Hazuki Kato, Tomas J. Acosta, Katsuya Kida, Takashi Shimizu, Motozumi Matsui
    • Organizer
      World Congress of Reproductive Biology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 乳用牛における妊娠末期のインスリン抵抗性とその産子の栄養代謝状態の関係2017

    • Author(s)
      川島千帆・岩瀬いづみ・加藤葉月・近藤萌里・木田克弥・清水隆・松井基純
    • Organizer
      第122回日本畜産学会
    • Place of Presentation
      神戸大学鶴甲第1キャンパス(兵庫県、神戸市)
    • Related Report
      2016 Research-status Report
  • [Presentation] 乳牛の採食状況の評価における3Dカメラの実用性の検証2016

    • Author(s)
      川島千帆・中村太一・細矢恭平・山岸啓介
    • Organizer
      第121回日本畜産学会
    • Place of Presentation
      日本獣医生命科学大学(東京都・武蔵野市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2020-03-30  

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