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Clarification of glucagon-like peptide secretion system and its application to the animal production

Research Project

Project/Area Number 15K07689
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Animal production science
Research InstitutionShinshu University

Principal Investigator

HIRAMATSU KOHZY  信州大学, 学術研究院農学系, 教授 (80238386)

Co-Investigator(Renkei-kenkyūsha) KITA Kazumi  岩手大学, 農学部, 教授 (20221913)
WATANABE Takafumi  酪農学園大学, 獣医学部, 准教授 (50598216)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywordsグルカゴン様ペプチド / 組織形態 / 内分泌 / ニワトリ / 機能形態 / 小腸 / 消化管内分泌 / 免疫組織化学
Outline of Final Research Achievements

Glucagon-like peptide (GLP)-1 coexisted with neurotensin (NT) in the same cell of the chicken small intestine. These cells mainly appeared in the crypt. They, however, specialized in cells which produce only NT in the villous epithelium. Amino acids in the diet influenced the expression of mRNA of proglucagon which is the precursor of GLP. Addition of whole egg powder induced the proliferation of enterocytes and goblet cells in small intestine.
These results indicate that protein and amino acids in the diet stimulate the secretion of GLP from L cells in the chicken intestine.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (13 results)

All 2018 2017 2016 2015

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (9 results) (of which Invited: 1 results)

  • [Journal Article] Glucagon-like Peptide-1 Receptor Expression in the Pancreatic D Cells of Three Avian Species; White Leghorn Chickens, Northern Bobwhites, and Common Ostriches2018

    • Author(s)
      Takafumi Watanabe, Kohzy Hiramatsu, Kei Nishimura, Tamao Ono
    • Journal Title

      The Journal of Poultry Science

      Volume: 55 Issue: 3 Pages: 199-203

    • DOI

      10.2141/jpsa.0170185

    • NAID

      130007418775

    • ISSN
      1346-7395, 1349-0486
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Glucagon-like peptide-1 is co-localized with neurotensin in the chicken ileum2017

    • Author(s)
      Kei Nishimura, Kohzy Hiramatsu, Takafumi Watamabe, Kazumi Kita
    • Journal Title

      Cell and Tissue Research

      Volume: 368 Issue: 2 Pages: 277-286

    • DOI

      10.1007/s00441-016-2561-0

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Dynamics of L cells along the crypt-villous axis in the chicken ileum2016

    • Author(s)
      K. Nishimura, K. Hiramatsu, T. Watanabe
    • Journal Title

      Domestic Animal Endocrinology

      Volume: 56 Pages: 70-74

    • DOI

      10.1016/j.domaniend.2016.02.010

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] ホエイ投与がニワトリ消化管粘膜に与える影響2016

    • Author(s)
      仁木小春、平松浩二、西村佳、渡邉敬文、伊藤謙、喜多一美
    • Journal Title

      北信越畜産学会報

      Volume: 112 Pages: 37-42

    • NAID

      40020737004

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 食餌中のタンパク質がニワトリ小腸におけるプログルカゴンmRNA発現に与える影響2018

    • Author(s)
      平松浩二、渡邉亮、渡邉敬文
    • Organizer
      日本畜産学会第124回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ニワトリ小腸におけるペプチドホルモンの共局在2017

    • Author(s)
      平松浩二、渡邉敬文、岩田誠
    • Organizer
      日本畜産学会第123回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ニワトリ回腸におけるグルカゴン様ペプチド1及びニューロテンシンの共局在に関する定量解析2016

    • Author(s)
      西村佳、平松浩二、渡邉敬文
    • Organizer
      第159回日本獣医学会学術集会
    • Place of Presentation
      日本大学生物資源科学部(神奈川県藤沢市)
    • Year and Date
      2016-09-08
    • Related Report
      2016 Research-status Report
  • [Presentation] ニワトリ回腸における陰窩-絨毛軸に沿ったL細胞の動態2016

    • Author(s)
      西村佳、平松浩二、渡邉敬文
    • Organizer
      日本家禽学会2016年度春季大会
    • Place of Presentation
      日本獣医生命科学大学
    • Year and Date
      2016-03-30
    • Related Report
      2015 Research-status Report
  • [Presentation] 全卵粉投与がニワトリ小腸のL細胞に与える影響2016

    • Author(s)
      仁木小春、平松浩二、西村佳、渡邉敬文
    • Organizer
      日本家禽学会2016年度春季大会
    • Place of Presentation
      日本獣医生命科学大学
    • Year and Date
      2016-03-30
    • Related Report
      2015 Research-status Report
  • [Presentation] 鳥類の膵島-細胞構成、神経支配、ホルモン調節-2016

    • Author(s)
      平松浩二、渡邉敬文
    • Organizer
      第121回日本解剖学会
    • Place of Presentation
      ビッグパレットふくしま(福島県郡山市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] ニワトリ小腸における粘膜上皮細胞のライフサイクル2015

    • Author(s)
      西村佳、平松浩二、渡邉敬文
    • Organizer
      日本家禽学会2015年度秋季大会
    • Place of Presentation
      酪農学園大学
    • Year and Date
      2015-09-10
    • Related Report
      2015 Research-status Report
  • [Presentation] 全卵粉給餌がニワトリ小腸のL細胞に与える影響2015

    • Author(s)
      仁木小春、平松浩二、渡邉敬文、西村佳
    • Organizer
      日本家禽学会2015年度秋季大会
    • Place of Presentation
      酪農学園大学
    • Year and Date
      2015-09-10
    • Related Report
      2015 Research-status Report
  • [Presentation] L細胞の分泌顆粒形態及び含有ホルモン割合は位置により変わる2015

    • Author(s)
      西村佳、平松浩二、渡邉敬文、仁木小春
    • Organizer
      第158回日本獣医学会学術集会
    • Place of Presentation
      北里大学獣医学部
    • Year and Date
      2015-09-09
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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