Clarification of glucagon-like peptide secretion system and its application to the animal production
| Project/Area Number |
15K07689
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Animal production science
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KITA Kazumi 岩手大学, 農学部, 教授 (20221913)
WATANABE Takafumi 酪農学園大学, 獣医学部, 准教授 (50598216)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | グルカゴン様ペプチド / 組織形態 / 内分泌 / ニワトリ / 機能形態 / 小腸 / 消化管内分泌 / 免疫組織化学 |
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| Outline of Final Research Achievements |
Glucagon-like peptide (GLP)-1 coexisted with neurotensin (NT) in the same cell of the chicken small intestine. These cells mainly appeared in the crypt. They, however, specialized in cells which produce only NT in the villous epithelium. Amino acids in the diet influenced the expression of mRNA of proglucagon which is the precursor of GLP. Addition of whole egg powder induced the proliferation of enterocytes and goblet cells in small intestine.
These results indicate that protein and amino acids in the diet stimulate the secretion of GLP from L cells in the chicken intestine.
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Report
(4 results)
Research Products
(13 results)
