| Project/Area Number |
15K07694
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Animal production science
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
豊後 貴嗣 広島大学, 生物圏科学研究科, 教授 (40325361)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 暑熱ストレス / ニワトリ / アミノ酸 / ニューロペプチド / Heat-stress / Chicks (layer) / Chicks (broiler) / Thermotolerance / NPY / GnIH / L-Leucine / L-Citrulline / Chicks / Broilers / Metabolism / Chick / Body temperature / Heat stress / Stress hormone / Amino acids |
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| Outline of Final Research Achievements |
The purpose of the project was to understand the mechanisms and functions of neuropeptides and amino acids to adapt heat stress. It was revealed that neuropeptide Y (NPY) was increased in chick brain under heat stress. Subsequently, we revealed that central injection of NPY reduced body temperature and afforded therotolerance in fasted chicks. Central NPY also reduced stress hormone, corticosterone, in fasted chicks. It was further found that heat stress caused to reduce plasma citrulline (Cit). Oral administration of L-Cit reduced body temperature and afforded thermotolerance in chicks. Thermal manipulation during embrogenesis caused to reduce leucine (Leu) concentrations in the brain and liver of embroys. We injected L-Leu into the fertilized eggs and found that in ovo L-Leu afforded thermotolerance in broiler chicks. Therefore, this project developed some novel ideas to utilize amino acids and neuropeptides to control heat stress problems.
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