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The research for relationships among genome DNA methylation polymorphism and marbling in Japanese beef cattle

Research Project

Project/Area Number 15K07696
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Animal production science
Research InstitutionMiyagi University

Principal Investigator

Yoshihito Suda  宮城大学, 食産業学群(部), 教授 (90404847)

Co-Investigator(Kenkyū-buntansha) 小林 栄治  国立研究開発法人農業・食品産業技術総合研究機構, 畜産研究部門, ユニット長 (00186727)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords黒毛和種 / DNA / メチル化 / 多型 / 脂肪交雑 / 枝肉成績 / DNAメチル化 / 肉質 / 霜降り / エピジェネティクス / 改良 / 育種価 / ASS1 / 脂肪前駆細胞 / DNAメチレーション / ゲノムDNA / ロース芯 / MS-RDA法 / メチル化チップ
Outline of Final Research Achievements

This study’s aims are to examine relationships among DNA methylation patterns at the slaughter after fattening and economic carcass traits of JB siblings of two sires. Genomic DNA samples were collected from adipose tissues around the kidneys in each 100 JBs produced from 2 sires (Sire A and B) have parent-child relation, totaling of 200 JBs. Correlation analysis and analysis of variance (ANOVA) are performed by using SAS program, version 9.1. The CG rich regions in the upstream regions of seven genes, APC_2, CDKN2A_1, CDKN2A_2, CDKN2B, GSTP1, MGMT and SFRP1 of 24 genes were very high DNA methylation level, and DMP in the other genes was similar between 2 sires with parent-child relation. Additionally, CDKN2A_2 and RB1 was specific condition. Correlation between subcutaneous fat thickness and CHFR was 0.73 at 5% significance level in JBs of sire A.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (8 results)

All 2017 2016 2015 Other

All Presentation (7 results) (of which Int'l Joint Research: 3 results) Remarks (1 results)

  • [Presentation] 黒毛和種におけるASS1遺伝子上流域のメチル化修飾に関する枝肉格付け間比較2017

    • Author(s)
      相澤正樹,福島小百合,小林栄治,麻生久,鈴木啓一,須田義人
    • Organizer
      日本畜産学会 第122回大会
    • Place of Presentation
      神戸,神戸大学
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] 黒毛和種におけるASS1遺伝子上流域のメチル化修飾に関する枝肉格付け間比較2017

    • Author(s)
      相澤正樹,福島小百合,小林栄治,麻生久,鈴木啓一,須田義人
    • Organizer
      第122回 日本畜産学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Correlation between DNA methylation in CHFR gene promoter and economic traits in J. Black cattle2016

    • Author(s)
      Y. Suda, E. Kobayashi, Y. Saito, K. Kato, K. Suzuki
    • Organizer
      67th Annual Meeting of the European Federation of Animal Science
    • Place of Presentation
      Belfast, UK
    • Year and Date
      2016-08-29
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Correlation between DNA methylation in CHFR gene promoter and economic traits in J. Black cattle2016

    • Author(s)
      Y. Suda, E. Kobayashi, Y. Saito, K. Kato, K. Suzuki
    • Organizer
      European Federation of Animal Science 2016
    • Place of Presentation
      Belfast, UK
    • Year and Date
      2016-08-29
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] マウスにおけるウシ乳房原因菌炎症反応に対するラウリン酸の効果2016

    • Author(s)
      須田義人,佐々木菜摘,加茂祐樹
    • Organizer
      第121回日本畜産学会
    • Place of Presentation
      日本獣医生命科学大学
    • Year and Date
      2016-03-27
    • Related Report
      2015 Research-status Report
  • [Presentation] Expression profile of complement C3 and its beta chain (C3b) in uterine epithelium of mice2015

    • Author(s)
      Yoshihito Suda, Yuki Kamo, Sayuri Fukushima, Keigo Nakamura
    • Organizer
      Biochemistry and Molecular Biology 2015
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] The effect of lauric acid on inflammation response caused by cow fungal mastitis in mice2015

    • Author(s)
      Suda Yoshihito, Sasaki Natsumi, Masumizu Yuki
    • Organizer
      European Federation of Animal Science 2015
    • Place of Presentation
      Warsaw, Poland
    • Year and Date
      2015-08-31
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Remarks] 家畜改良にみられる進化的な遺伝的改良量とエピジェネティクスの関係

    • URL

      http://www.myu.ac.jp/site/farm/sudayof.html

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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