Functional analysis of bovine endogenous retrovirus to improve pregnancy rate
Project/Area Number |
15K07697
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Animal production science
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Research Institution | Tokyo University of Science |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 内在性レトロウイルス / ウシ / 胎盤形成 / 胎盤 / WNT / 胎盤機能獲得 / 胚機能獲得 |
Outline of Final Research Achievements |
The purpose of this study was to search for endogenous retroviruses expressed in bovine conceptus during peri-implantation (peri-attachment) and to analyze the function of their endogenous retrovirus genes useful for pregnancy process and placenta formation. As a result, BERV-K3 which is highly expressed in bovine placenta was found. It was revealed that expression of the BERV-K3 is induced by the canonical WNT signal required for placenta formation. We also found bovine endogenous retroviruses present on the X chromosome or the Y chromosome, and revealed that they are expressed specifically in pre-attachment conceptus. These findings have been found to be important discoveries indicating the involvement of endogenous retroviruses in bovine pregnancy process and to be possible candidate factors for the newly selection of high conception embryo/conceptus.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] The DNA methylation profile of liver tumors in C3H mice and identification of differentially methylated regions involved in the regulation of tumorigenic genes.2018
Author(s)
Matsushita J, Okamura K, Nakabayashi K, Suzuki T, Horibe Y, Kawai T, Sakurai T, Yamashita S, Higami Y, Ichihara G, Hata K, Nohara K
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Journal Title
BMC Cancer
Volume: 18
Issue: 1
Pages: 317-317
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Novel endogenous retrovirus-derived transcript expressed in the bovine placenta is regulated by WNT signaling.2017
Author(s)
Sakurai T, Nakagawa S, Bai H, Bai R, Kusama K, Ideta A, Aoyagi Y, Kaneko K, Iga K, Yasuda J, Miyazawa T, Imakawa K.
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Journal Title
Biochemical Journal
Volume: 474
Issue: 20
Pages: 3499-3512
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Preliminary characterization of a murine model for 1-bromopropane neurotoxicity: Role of cytochrome P4502016
Author(s)
C. Zong, C.E. Garner, C. Huang, X. Zhang, L. Zhang, J. Chang, S. Toyokuni, H. Ito, M. Kato, T. Sakurai, S. Ichihara, G. Ichihara
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Journal Title
Toxicological Letters
Volume: 258
Pages: 249-258
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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