| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Intestinal epithelial barrier dysfunction and increased permeability is supposed to cause microbial or microbial components translocation which may induce low-grade inflammation in various diseases. It has also been suggested that high-fat diet-induced obesity causes gut dysbiosis that drives inflammation in various diseases. Moreover, the relation of gut dysbiosis to intestinal barrier dysfunction has gradually been clarified, but mechanisms are unknown.
This study strongly suggested that potential probiotic which binds to sulfated sugar chains found in gut mucin prevents intestinal epithelial barrier dysfunction through improving the profile of gut microbiota in high-fat diet-induced obesity model mouse. Furthermore, we suggest a novel mechanism for barrier dysfunction on a high-fat diet involving the effect of metabolites of cholic acid which is one of bile acids by gut microbiota.
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