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Role of prolonged release of CXCL8 during bovine mastitis caused by intramammary infection of Staphylococcus aureus

Research Project

Project/Area Number 15K07731
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Veterinary medical science
Research InstitutionNational Agriculture and Food Research Organization

Principal Investigator

Watanabe Atsushi  国立研究開発法人農業・食品産業技術総合研究機構, 動物衛生研究部門, 上級研究員 (60442810)

Co-Investigator(Renkei-kenkyūsha) KIMURA KAZUHIRO  国立大学法人北海道大学, 大学院獣医学研究科, 教授 (30192561)
KIMURA TAKASHI  国立大学法人北海道大学, 大学院獣医学研究科, 教授 (90261338)
HATA EIJI  国立研究開発法人農業・食品産業技術総合研究機構, 動物衛生研究部門, 上級研究員 (50355153)
NAKAJIMA KEI-ICHI  国立研究開発法人農業・食品産業技術総合研究機構, 北海道農業研究センター, 上級研究員 (70362150)
HAYASHI TOMOHITO  国立研究開発法人農業・食品産業技術総合研究機構, 動物衛生研究部門, 上席研究員 (90297630)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords獣医学 / 畜産学 / 乳房炎 / 黄色ブドウ球菌 / 好中球 / 感染症 / 免疫学 / 生体分子 / 動物
Outline of Final Research Achievements

On the prolonged release of chemokine CXCL8 during Staphylococcus aureus mastitis, it was suggested that expression of CXCL8 in bovine mammary epithelial cell is mainly induced by stimulation with lipoteichoic acid of Staphylococcus aureus and inflammatory lactoferrin-derived peptides (released from lactoferrin digested with elastase) is partially involved in the induction of CXCL8. On the prolonged release of neutrophil elastase in the Staphylococcal mastitis, the enzyme is released from the neutrophil which died by necrosis or by formation of neutrophil extracellular traps.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (5 results)

All 2017 2016 2015

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Characteristics of mammary secretions from Holstein cows at approximately 10 days before parturition: with or without intramammary infection2017

    • Author(s)
      Watanabe Atsushi、Hata Eiji、Slama Petr、Kimura Kazuhiro、Hirai Tsunao
    • Journal Title

      Journal of Applied Animal Research

      Volume: 46 Issue: 1 Pages: 604-608

    • DOI

      10.1080/09712119.2017.1368524

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The cell wall component lipoteichoic acid of <i>Staphylococcus aureus</i> induces chemokine gene expression in bovine mammary epithelial cells2016

    • Author(s)
      Yoshio Kiku, Yuya Nagasawa, Fuyuko Tanabe, Kazue Sugawara, Atsushi Watanabe, Eiji Hata, Tomomi Ozawa. Kei-ichi Nakajima, Toshiro Arai, Tomohito Hayashi
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 78 Issue: 9 Pages: 1505-1510

    • DOI

      10.1292/jvms.15-0706

    • NAID

      130005598048

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Characteristics of mastitic mammary secretions from Holstein cows at 8-12 days before parturition2016

    • Author(s)
      Atsushi Watanabe, Eiji Hata, Tsunao HIrai
    • Organizer
      29th World Buiatrics Congress
    • Place of Presentation
      Dublin, Ireland
    • Year and Date
      2016-07-03
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Lymphocyte apoptosis and CD44 expression during inflammatory response of bovine mammary gland induced by lipopolysaccharide2015

    • Author(s)
      Petr Slama, Zbysek Sladek, Eliska Kabourkova, Zdenek Havlicek, Atsushi Watanabe, Jong Young Kwak
    • Organizer
      4th European Congress of Immunology
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2015-09-06
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Possible involvement of neutrophil elastase and inflammatory lactoferrin-derived peptides in the development of bovine mastitis induced by intramammary infusion of Staphylococcus aureus in the early dry period2015

    • Author(s)
      Atsushi Watanabe, Eiji Hata, Petr Slama, Kouichi Kadota, Yukio Chikayama, Yoshiharu Ishikawa, Kazuhiro Kimura
    • Organizer
      The Congress on Controversies & Consensus in Bovine Health, Industry & Economics
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2015-08-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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