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Possible involvement of Nrf2 in breakdown of liver regeneration program

Research Project

Project/Area Number 15K07732
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Veterinary medical science
Research InstitutionYamazaki Gakuen University (2017)
National Institute of Health Sciences (2015-2016)

Principal Investigator

Umemura Takashi  ヤマザキ学園大学, 動物看護学部, 教授 (50185071)

Co-Investigator(Kenkyū-buntansha) 高須 伸二  国立医薬品食品衛生研究所, 病理部, 主任研究官 (00597891)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords肝再生 / Nrf2 / 慢性増殖刺激 / Notchシグナル / Stat3 / 転写因子Nrf2 / 肝細胞腫瘍 / 結節性再生性肝細胞過形成 / 部分肝切除
Outline of Final Research Achievements

We investigated possible involvement of Nrf2 in breakdown of liver regeneration program through analysis of nodular hepatocyte regeneration model as chronic liver regeneration and partial hepatectomy model as acute liver regeneration using Nrf2 knockout mice. In nodular hepatocyte regeneration model, activation of Delta-Notch signaling was found in nodular regenerative hepatocellular hyperplasia and hepatocellular adenoma, but the extent in the latter was more prominent, indicating that activation of Notch signaling might be a key factor to acquire neoplastic properties. In partial hepatectomy model, Nrf2 was considered to be required on termination of liver regeneration. Further studies for the interaction between Nrf2 and Notch in ON/OFF regulation of chronic liver regeneration process were needed.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (3 results)

All 2017

All Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Piperonyl butoxide誘発マウス結節性再生性肝細胞過形成の腫瘍性病変との分子病理学的差異2017

    • Author(s)
      高須伸二,横尾諭,木島綾希,石井雄二,小川久美子,梅村隆志
    • Organizer
      第33回日本毒性病理学会学術集会
    • Place of Presentation
      ビッグ・アイ
    • Year and Date
      2017-01-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 急性的な増殖刺激により惹起される肝細胞再生過程におけるNrf2の関与2017

    • Author(s)
      高須伸二,石井雄二,木島綾希,小川久美子,梅村隆志
    • Organizer
      第44回日本毒性学会学術年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Molecular pathological differences between nodular regenerative hepatocellular hyperplasias and hepatocellular adenoma induced by long term exposure of piperonyl butoxid to mice.2017

    • Author(s)
      Takasu S, Yokoo Y, Ishii Y, Kijima A, Ogawa K, Umemura T
    • Organizer
      15th European Congress of Toxicologic Pathology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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