Effects of chemically modified synthetic microRNA-205 on spontaneous canine melanoma.

• Project/Area Number: 15K07742
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Veterinary medical science
• Research Institution: Gifu University
• Principal Investigator: MORI Takashi 岐阜大学, 応用生物科学部, 教授 (40402218)
• Co-Investigator(Kenkyū-buntansha): 野口 俊助 大阪府立大学, 生命環境科学研究科, 准教授 (10701295) ; 酒井 洋樹 岐阜大学, 応用生物科学部, 准教授 (40283288)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: microRNA / melanoma / dog / メラノーマ / 疾患モデル動物

Outline of Final Research Achievements

The purpose of this study was to evaluate effects of chemically modified synthetic microRNA-205 (miR-205) on spontaneous canine melanoma. A total of 9 dogs were included in this study. 4 cases obtained complete remission (CR). One case was partial response (PR), and 3 cases were stable disease (SD). 2 cases were progressive disease (PD). There were not any side effects in all cases during miR-205 treatment.