Recearch of gd T cell function in the respiratory mucosal immune system of Japanese Black calves
| Project/Area Number |
15K07748
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Veterinary medical science
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| Research Institution | Rakuno Gakuen University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
松田 一哉 酪農学園大学, 獣医学群, 准教授 (60405660)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | γδT細胞 / 呼吸器粘膜 / 誘導組織 / サイトカイン / リンフォイドケモカイン / 黒毛和種 / 子牛 |
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| Outline of Final Research Achievements |
The cytokines and lymphoid chemokines of γδ T cells in the Japanese Black (JB) calves were investigated. As a result, the expression of cytokines (IL-17A, IFN-g) and B cell activate chemokine (CXCL-12, CXCL-13) in the JB calves were lower than those in the Holstein calves.
In the analysis of the expression of cytokines of γδ T cells with stimulation of bacterial antigens in calves, level of TNF-α increased in the this cells with stimulation of LPS or PG, and levels of IL-17A and IL-23 increaed with PG stimulation.
In the analys of immunopathophysiological analysis to clarify the distribution pattern of γδ T cells in respiratory mucosa in the calves, γδ cells were found in the amygdala compared to other tissues of the respiratory tract, and lower numbers of amygdala γδ T cells were observed in the calves with thymic atrophy.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Effect of supplemental vitamin E on the peripheral blood leukocyte population in Japanese Black calves2015
Author(s)
Otomaru, K., Saito, S., Endo, K., Kohiruimaki, M., Fukuyama, S., Ohtsuka, H.
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Journal Title
Journal of Veterinary Medical Science
Volume: 77
Issue: 8
Pages: 985-988
DOI
NAID
ISSN
0916-7250, 1347-7439
Related Report
Peer Reviewed / Open Access
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