Study on IgG involved in dietary allergies in dogs and cats
Project/Area Number |
15K07757
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Veterinary medical science
|
Research Institution | Azabu University |
Principal Investigator |
|
Project Period (FY) |
2015-10-21 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 炭酸脱水酵素 / 食事性アレルギー / IgG抗体 / 腎疾患 / CA抗体 / 腎疾患マーカー / 変性壊死 / 炭酸脱水酵素アイソザイム / IgG / 犬猫の食事性アレルギー / CAアイソザイム / 遅延型食事性アレルギー / BSA抗体 / 自己抗体 |
Outline of Final Research Achievements |
We found a dog and cat that produced antibodies against carbonic anhydrase (CA) in serum. CA was antigenic in the pet food. Since CA is common antigenic among mammals, it is presumed that it is a dietary allergy. When the CA-3 IgG antibody was intramuscularly injected into rats, no decrease in muscle strength was observed, but the increase in muscle weight was suppressed. CA-1, IgG antibody was intramuscularly injected into rats. On the 21th day after the administration, the whole blood was taken and a pathological specimen of the kidney was prepared. BUN, IP, Na, Cl, ALT, LDH, AMY, TG, T - CHO, HDL-C, clusterin, αGST and kIM-1 showed a significant increase in the blood test. In kidney pathological examination, degenerative necrosis was observed in the proximal tubule.
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Report
(4 results)
Research Products
(1 results)