| Project/Area Number |
15K07765
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrative animal science
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| Research Institution | Gifu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
齋藤 正一郎 岐阜大学, 応用生物科学部, 准教授 (60325371)
海野 年弘 岐阜大学, 応用生物科学部, 教授 (90252121)
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| Research Collaborator |
TANAHASHI Yasuyuki
SUZUKI Kasumi
ITO Atsushi
SAKUMA Emi
NAGANO Hiroshi
FIROJ Alom
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 神経 / ムスカリン受容体 / 内臓平滑筋 / ムスカリン受容体サブタイプ / 腸神経―平滑筋接合部電位 / 収縮 / 視床下部 / バソプレシン / 腸神経 / 平滑筋 / 情報伝達 |
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| Outline of Final Research Achievements |
Among M1 to M5 muscarinic receptor subtypes, M2 and M3 receptors are located to not only a smooth muscle cell but also various enteric nerve cells. In this study, to make clear the mechanisms of peristalsis of the large intestine, we have investigated the role of M2 and M3 receptors on the enteric nerves, using muscarinic receptor subtypes knockout mice. In consequence of the study, both M2 and M3 receptor subtypes enhanced the ATP-mediated neuromuscular transmissions in the smooth muscle cells in the large intestine. In addition, M2 receptor-mediated contraction was larger than M3-mediated one. Furthermore, it is also expected that novel signaling molecules may be involved in the both M2 and M3 receptor-mediated contractions in the large intestine.
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