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Analysis of the relationship between T cell repertory and incidence of laboratory animal allergy by environmental factors

Research Project

Project/Area Number 15K07776
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Integrative animal science
Research InstitutionHokkaido University

Principal Investigator

Tosa Noriko  北海道大学, 医学研究院, 助教 (20312415)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords動物アレルギー / 食物アレルギー / 胎仔期 / 幼若期 / IgE / IL-13 / Can f 1 / 実験動物 / 犬アレルゲン / 環境要因 / 胸腺 / レパトア形成 / Tリンパ球 / Th1/Th2バランス / Lipocalin
Outline of Final Research Achievements

In this study, exposure of antigens to fetus or juvenile mice suppressed the induction of laboratory animal allergy. These results suggest incidence of laboratory animal allergy is influenced by environmental factors and the relationship between the influence and establishment of T cell repertory as T cell repertory is established in fetus or juvenile mice. Moreover, animal allergen Can f 1-specific IgE and IL13 levels in the mice immunized with Can f 1 were influenced by aluminum hydroxide, differing from the results for immunization with OVA as a food allergen. These results suggest that the immune mechanism for laboratory animal allergy is different from that with food allergy.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (3 results)

All 2017 2016

All Presentation (3 results)

  • [Presentation] 犬アレルゲン(Can f 1)感作誘導による免疫応答に関する卵白アルブミン(OVA)との比較解析2017

    • Author(s)
      土佐紀子、吉松組子、有川二郎
    • Organizer
      第64回実験動物学会
    • Place of Presentation
      ブックパレットふくしま(福島県福島市)
    • Year and Date
      2017-05-25
    • Related Report
      2016 Research-status Report
  • [Presentation] 犬アレルゲン(Can f 1)感作誘導による免疫応答に関する卵白アルブミン(OVA)との比較解析2017

    • Author(s)
      土佐紀子、吉松組子、有川二郎
    • Organizer
      第64回日本実験動物学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 犬アレルゲン(Can f 1)感作誘導におけるマウス系統特異的免疫応答の解析2016

    • Author(s)
      土佐紀子、吉松組子、有川二郎
    • Organizer
      第159回日本獣医学会学術集会
    • Place of Presentation
      日本大学湘南キャンパス(神奈川県藤沢市)
    • Year and Date
      2016-09-06
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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