| Project/Area Number |
15K07779
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrative animal science
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Research Collaborator |
Iwata Hisataka 東京農業大学, 農学部, 教授 (50385499)
Sugimoto Miki 京都大学, 大学院農学研究科, 助教 (20243074)
Kume Shinichi 京都大学, 大学院農学研究科, 教授 (90355454)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | エピジェネティクス / ニュートリエピジェネティクス / 初期胚 / 着床前胚 / ウシ / One-carbon metabolism / 受精卵 |
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| Outline of Final Research Achievements |
Availability of nutrients surrounding early embryos is one of the environmental factors that can change their epigenetics. In the present study, we demonstrated the indispensability of methionine adenosyltransferase (MAT), which converts methionine to S-adenosylmethionine, in mammalian preimplantation development, particularly in blastocyst development. Furthermore, we revealed a part of the basis of nutriepigenetics (control and/or changes of epigenetics by nutrients) by the exploration of MAT2A-associated genomic regions in bovine early embryos and the investigation of the roles of methionine metabolism and related nutrients i.e., B vitamins in development and epigenetic modifications of specific genes in early embryos.
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