| Project/Area Number |
15K07783
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrative animal science
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| Research Institution | Tokyo University of Agriculture |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
岩田 尚孝 東京農業大学, 農学部, 教授 (50385499)
桑山 岳人 東京農業大学, 農学部, 教授 (40215124)
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 加齢 / 妊娠 / 卵管 / 子宮 / 炎症 / 免疫 / 老化 |
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| Outline of Final Research Achievements |
In this study, we hypothesized that the decrease in pregnancy rate might be caused by the fall of the oviduct and uterine function and the excessive inflammatory state with aging, and the cow was verified as a model. From analysis of next-generation sequencers, old-derived oviduct cells had higher expression of inflammation-related gene groups (IL-1, S100A, etc.) than younger-derived oviduct cells. Aging induction candidate factors has been shown to induce inflammation of oviduct cells and abnormalities of fertilization and embryogenesis.
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| Academic Significance and Societal Importance of the Research Achievements |
加齢に伴う過剰な老化因子の蓄積が子宮・卵管細胞の慢性炎症を引き起こした。また、老化誘導候補因子が細胞の機能異常や発生異常を引き起こすことが分かった。以上から、妊娠に重要な卵管・子宮は加齢に伴い機能異常が起きることが判明し、その機序の一端を明らかにできたことから、これらの成果が老化制御法や治療法の開発に繋がることが期待できる。
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