| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
By comparing cloned mice derived from antigen-specific T cells generated by applicants for the first time and mouse lines developed by crossbreeding of the cloned mice with inbred mice and the same and other cloned mice, we clarified the importance of T cell receptor (TCR) to thymic T cell development and T cell subset differentiation. Antigen-induced T cell responses in T cell cloned mice were stronger than those of corresponding TCR-transgenic mice. Furthermore, the in vivo antigen responses in mice expressing either alpha- or beta-chain of TCR derived from cloned mice were stronger than those of inbred mice. The usefulness of antigen specific T cell cloned mice for investigating immune systems and developing immune disease models.
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