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Basic study of stress related disorders based with stress-induced sleep disorder model mice

Research Project

Project/Area Number 15K07788
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Integrative animal science
Research InstitutionNational Institute of Advanced Industrial Science and Technology

Principal Investigator

Miyazaki Koyomi  国立研究開発法人産業技術総合研究所, 生命工学領域, 研究グループ長 (70358125)

Co-Investigator(Renkei-kenkyūsha) OISHI Katsutaka  産業技術総合研究所, バイオメディカル研究部門, 研究グループ長 (50338688)
Project Period (FY) 2015-10-21 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsストレス / 睡眠障害 / サーカディアンリズム / メンタルシンドローム / 腸内フローラ / 体温 / モデル動物 / マウス / 行動リズム / 不安障害
Outline of Final Research Achievements

In our previous study, we originally developed continuous chronic stress exposure system of mice. This system can induce chronic sleep disorder in mice, which shows typical sleepiness in active time and intermittent sleep during resting time. In this study we analyzed 1) which area in a brain is activated by chronic stress exposure, 2) whether chronic stress affects on immune system in whole body, 3) the effects of sleep disorder on neurodegenerative diseases, and 4) screening of natural compound which can improve the health condition in stressed animal and evaluation of the effect of compounds in mice. As a result, we found that chronic sleep disorder promoted the oxidative stress in a brain and progression of neurodegenerative disorders, induced an inflammation in whole body, and dramatically changing of intestinal flora in model mice.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (15 results)

All 2017 2016 Other

All Int'l Joint Research (3 results) Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (5 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] TISTR(Thailand)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Wageningen University(オランダ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] NSTDA, BIOTEC/TISTR(タイ)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Chronic sleep fragmentation exacerbates amyloid β deposition in Alzheimer’s disease model mice2017

    • Author(s)
      Minakawa Eiko N.、Miyazaki Koyomi、Maruo Kazushi、Yagihara Hiroko、Fujita Hiromi、Wada Keiji、Nagai Yoshitaka
    • Journal Title

      Neurosci. Lett.

      Volume: 653 Pages: 362-369

    • DOI

      10.1016/j.neulet.2017.05.054

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The anti-inflammatory effect of Agaricus brasiliensis is partly due to its linoleic acid content.2017

    • Author(s)
      Papawee Saiki, Yasuhiro Kawano, Van Griensven LJLD, Koyomi Miyazaki.
    • Journal Title

      Food Function

      Volume: 8 Issue: 11 Pages: 4150-4158

    • DOI

      10.1039/c7fo01172e

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of lipopolysaccharide on circadian clock genes Per2 and Bmal1 in mouse ovary.2017

    • Author(s)
      Shimizu T, Watanabe K, Anayama N, Miyazaki K.
    • Journal Title

      J Physiol Sci.

      Volume: 印刷中 Issue: 5 Pages: 623-628

    • DOI

      10.1007/s12576-017-0532-1

    • NAID

      40021302116

    • Related Report
      2016 Research-status Report
  • [Presentation] 中途覚醒の増加はアルツハイマー病モデルマウスのアミロイドβ病理を悪化させる2017

    • Author(s)
      皆川栄子、宮崎歴、丸尾和司、八木原紘子、藤田寛美、和田圭司、永井義隆
    • Organizer
      日本睡眠学会第42回定期学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 天然化合物のパワーを生かしたこころとからだを守る技術の開発2017

    • Author(s)
      宮崎歴
    • Organizer
      第1回沖縄県産学官連携セミナー
    • Related Report
      2017 Annual Research Report
  • [Presentation] Bioassay of Functional Food Development for Circadian Rhythm and Sleep Disorder2017

    • Author(s)
      Koyomi Miyazaki
    • Organizer
      TISTR and AIST Mini Joint Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Circadian oscillation of luminescence in testis explants from Per2::luc mouse2017

    • Author(s)
      Hideaki Oike, Nanako Itoh, Koyomi Miyazaki
    • Organizer
      XV European Biological Rhythms Society Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マウス妊娠黄体の形成と維持における時計遺伝子Bmal1の関与2016

    • Author(s)
      小林桃子、渡邉佳耶、宮崎歴、宮本明夫、古林与志安、 榛葉繁紀、 清水隆
    • Organizer
      第109回日本繁殖生物学会大会
    • Place of Presentation
      麻布大学、相模原市
    • Year and Date
      2016-09-13
    • Related Report
      2016 Research-status Report
  • [Remarks] 産業技術総合研究所 バイオメディカル研究部門 健康維持機能物質開発研究グループ

    • URL

      https://unit.aist.go.jp/bmd/biomed-pas/index.html

    • Related Report
      2016 Research-status Report
  • [Remarks] 産業技術総合研究所 バイオメディカル研究部門

    • URL

      https://unit.aist.go.jp/bmd/

    • Related Report
      2016 Research-status Report
  • [Remarks] バイオメディカル研究部門健康維持機能物質開発研究グループ

    • URL

      https://unit.aist.go.jp/bmd/biomed-pas/

    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] 小動物飼育装置及び小動物飼育方法2016

    • Inventor(s)
      メルクエスト、産業技術総合研究所
    • Industrial Property Rights Holder
      メルクエスト、産業技術総合研究所
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-101237
    • Filing Date
      2016-05-20
    • Related Report
      2016 Research-status Report

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Published: 2015-10-21   Modified: 2022-08-19  

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