| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Various conditions such as ischemia and spinal cord injury are treated using regenerative medicine based on stem cell transplantation. Basic studies using small laboratory animals have shown that transplanted cells can improve blood flow at infarcted regions, reconstruct an injured spinal cord and provide motor ability. Here, we established the safety and applicability system using the MRI-based cell tracking system combination with various disease models in nonhuman primates. We confirmed the isolated cells using FACS and then labeled them with FIP. The labeled cells in several organs emitted signals that were detected by MRI and the remains of labeled cells were identified in tissue segments from not only the lung but also the brain. This system in nonhuman primates might be a useful way to efficiently design safer strategies for regenerative medicine.
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