Establishment of MRI based cell-tracking system for regenerative medicine in nonhuman primate
Project/Area Number |
15K07789
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Integrative animal science
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Research Institution | National Institutes of Biomedical Innovation, Health and Nutrition |
Principal Investigator |
AGEYAMA Naohide 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 霊長類医科学研究センター, 主任研究員 (50399458)
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Research Collaborator |
FUJISHIRO Yasuyo
NAKAYAMA Shunya
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 霊長類 / MRI / 再生医療 / 幹細胞 / 移植 / 疾患モデル / 循環器疾患 / 内分泌疾患 / 肝細胞 |
Outline of Final Research Achievements |
Various conditions such as ischemia and spinal cord injury are treated using regenerative medicine based on stem cell transplantation. Basic studies using small laboratory animals have shown that transplanted cells can improve blood flow at infarcted regions, reconstruct an injured spinal cord and provide motor ability. Here, we established the safety and applicability system using the MRI-based cell tracking system combination with various disease models in nonhuman primates. We confirmed the isolated cells using FACS and then labeled them with FIP. The labeled cells in several organs emitted signals that were detected by MRI and the remains of labeled cells were identified in tissue segments from not only the lung but also the brain. This system in nonhuman primates might be a useful way to efficiently design safer strategies for regenerative medicine.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Tracking cells implanted into cynomolgus monkeys (<i>Macaca fascicularis</i>) using MRI2016
Author(s)
Fujishiro Y, Koie H, Shibata H, Okabayashi S, Katakai Y, Ohno C, Kanayama K, Yasutomi Y, Ageyama N.
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Journal Title
Experimental Animals
Volume: 65
Issue: 3
Pages: 311-318
DOI
NAID
ISSN
0007-5124, 1341-1357, 1881-7122
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 霊長類を用いた再生医療評価システムの検討2016
Author(s)
揚山 直英, 鯉江 洋, 藤城 康世, 中山 駿矢, 柴田 宏昭, 片貝 祐子, 金山 喜一, 長船 健二, 保富 康宏
Organizer
第159回日本獣医学会学術集会
Place of Presentation
神奈川(日本大学)
Year and Date
2016-09-06
Related Report
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