| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Insect cuticle is a matrix composed of chitin fiber and chitin-binding proteins. A serine protease in the cuticular matrix is present as an inactive precursor, but is activated by stimuli like injury or invasion of pathogens. Inside the cuticle, the activated protease degrades specifically a cuticular component, and the fragments can be signal molecules to send signals that epithelial barrier is broken and the substances outside can go into body cavity. The main purpose of this study is to reveal the biological meanings of this phenomenon. The in-vitro system to control activation of the protease has been established, which can contribute to the further analyses of this potential signaling mechanisms in insect cuticle.
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