| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Based on our finding that the selenium which is the essential trace element influences epigenetic regulations, we focused on selenoprotein H (SelH), which is known as the only nuclear protein among selenoproteins. By the analysis of SelH knock down ES cells, we found out that SelH is effect on the DNA methylation status and histone modifications at several pluripotent marker genes, indicating that SelH functions as one of epigenetic factors. We expected that the identification of SelH containing protein complex, which is in progress, might contribute to understanding how SelH participates in epigenetic regulation.
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