Identification of the selenoprotein complex functioning epigenetic regulation
| Project/Area Number |
15K07836
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Hirosawa Mitsuko 東京大学, 大学院農学生命科学研究科(農学部), 助教 (60533982)
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| Project Period (FY) |
2015-10-21 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | セレノプロテイン / ヒストン修飾 / DNAメチル化 / ES細胞 / エピジェネティクス / タンパク質複合体 |
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| Outline of Final Research Achievements |
Based on our finding that the selenium which is the essential trace element influences epigenetic regulations, we focused on selenoprotein H (SelH), which is known as the only nuclear protein among selenoproteins. By the analysis of SelH knock down ES cells, we found out that SelH is effect on the DNA methylation status and histone modifications at several pluripotent marker genes, indicating that SelH functions as one of epigenetic factors. We expected that the identification of SelH containing protein complex, which is in progress, might contribute to understanding how SelH participates in epigenetic regulation.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Putative Epimutagens in Maternal Peripheral and Cord Blood Samples Identified Using Human Induced Pluripotent Stem Cells.2015
Author(s)
Arai Y, Hayakawa K, Arai D, Ito R, Iwasaki Y, Saito K, Akutsu K, Takatori S, Ishii R, Hayashi R, Izumi S, Sugino N, Kondo F, Horie M, Nakazawa H, Makino T, Hirosawa M, Shiota K, Ohgane J.
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Journal Title
Biomed Res Int.
Volume: 2015
Pages: 1-13
DOI
Related Report
Peer Reviewed / Open Access
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