Preparation of functional glyco-polymers and analysis of their cellular immune activities to develop anti-pollinosis drugs
| Project/Area Number |
15K07841
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | Okayama University |
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Principal Investigator |
MAEDA Megumi 岡山大学, 環境生命科学研究科, 准教授 (20434988)
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| Co-Investigator(Renkei-kenkyūsha) |
KIMURA Yoshinobu 岡山大学, 大学院環境生命科学研究科, 教授 (70195387)
OKANO Mitsuhiro 国際医療福祉大学, 医学部, 教授 (60304359)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 糖鎖ポリマー / 花粉アレルゲン / N-グリカン / 植物抗原性糖鎖 / ルイスa抗原 / Th2免疫応答 / 樹状細胞 / γ-ポリグルタミン酸 / HLA-DR / NFkB / Cry j1 / Cha o3 / Th1免疫応答 / IFN-γ産生 / ハイマンノース型糖鎖 / 動物複合型糖鎖 / スギ花粉症 / Th2 |
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| Outline of Final Research Achievements |
Three types of glycopolymers bearing multivalent N-glycans (plant complex type, high-mannose type, or animal complex type) were synthesized. Their suppressive functions on Th2 cellular immune response induced by Japanese cedar pollen allergen, Cry j1, were analyzed by using dendritic cells. And then, structural features of newly identified Japanese cypress pollen allergen, Cha o3, were analyzed. The glycoform of Cha o 3 is similar to those of major glycoallergens in cedar or cypress pollens (Cry j1 and Jun a1).
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Glycoform of a newly identified pollen allergen, Cha o 3, from Chamaecyparis obtusa (Japanese cypress, Hinoki).2017
Author(s)
Osada T, Maeda M, Tanabe C, Furuta K, Vavricka CJ, Sasaki E, Okano M, Kimura Y.
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Journal Title
Carbohydr Res.
Volume: 448
Pages: 18-23
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Molecular characterization of tomato α1,3/4-fucosidase, a member of glycosyl hydrolase family 29, involved in degradation of plant complex type N-glycans.2017
Author(s)
Rahman, M.D., Maeda, M., Itano, S., Hossain, M.A., Ishimizu, T., Kimura, Y.
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Journal Title
J. Biochem.
Volume: 161
Pages: 421-432
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Glycoform analysis of a new major allergen, Cha o3, from Japanese cypress pollen2017
Author(s)
C. Tanabe, M. Maeda, T. Osada, E. Sasaki, M. Okano, Y. Kimura
Organizer
12th Carbohydrate Bioengineering Meeting（The CBM12）, Audi Max, Augasse 2-6, 1090 Vienna/Austria
Related Report
Int'l Joint Research
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