| Project/Area Number |
15K07842
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KAMESHITA ISAMU 香川大学, 農学部, 教授 (60127941)
SUGIYAMA YASUNORI 香川大学, 農学部, 助教 (10632599)
ISHIDA ATSUHIKO 広島大学, 大学院・総合科学研究科, 教授 (90212886)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | CaM kinase / phosphorylation / zebrafish / Dlx1 / phosphatase / CaMKK / CaMKI / CaMKIδ / CaMKIα / λ protein phosphatase / autophosphorylation / Dlx5 / ホスファターゼ抵抗性 / CaMKP |
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| Outline of Final Research Achievements |
Ca2+/calmodulin-dependent protein kinase I (CaMKI) is known to be activated by the upstream kinase, CaMK kinase. Recently, we have found that CaMKI-delta, one of the isoform of CaMKI, plays an important role in the generation of cartilage and fins during zebrafish embryogenesis. In this study, we found a CaMK kinase-independent activation mechanism of CaMKI-delta. In addition, we identified Dlx1 as a candidate for endogenous substrate of CaMKI-delta.
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