Activation mechanism and physiological functions of CaMKI-delta
| Project/Area Number |
15K07842
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KAMESHITA ISAMU 香川大学, 農学部, 教授 (60127941)
SUGIYAMA YASUNORI 香川大学, 農学部, 助教 (10632599)
ISHIDA ATSUHIKO 広島大学, 大学院・総合科学研究科, 教授 (90212886)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | CaM kinase / phosphorylation / zebrafish / Dlx1 / phosphatase / CaMKK / CaMKI / CaMKIδ / CaMKIα / λ protein phosphatase / autophosphorylation / Dlx5 / ホスファターゼ抵抗性 / CaMKP |
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| Outline of Final Research Achievements |
Ca2+/calmodulin-dependent protein kinase I (CaMKI) is known to be activated by the upstream kinase, CaMK kinase. Recently, we have found that CaMKI-delta, one of the isoform of CaMKI, plays an important role in the generation of cartilage and fins during zebrafish embryogenesis. In this study, we found a CaMK kinase-independent activation mechanism of CaMKI-delta. In addition, we identified Dlx1 as a candidate for endogenous substrate of CaMKI-delta.
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Report
(4 results)
Research Products
(27 results)
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[Presentation] ESTABLISHMENT of a NEW ESCHERICHIA COLI STRAIN CONSTITUTIVELY EXPRESSING LAMBDA PHOSPHATASE, and APPLICATION to the PREPARATION of HIGHLY ACTIVE CASEIN KINASE 12018
Author(s)
Akizuki, K., Toyama, T., Yamashita, M., Ishida, A., Kameshita, I. Sueyoshi, N.
Organizer
2018 IUBMB SEOUL (24th IUBMB Congress & 15th FAOBMB Congress)
Related Report
Int'l Joint Research
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