| Project/Area Number |
15K07846
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | Chubu University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KUSUDO Tatsuya 帝塚山学院大学, 人間科学部, 准教授 (00460535)
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| Research Collaborator |
HASHIMOTO Michihiro
TAKEUCHI Tamaki
OKADA Tadashi
ENDO Yuki
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 褐色脂肪細胞 / Creg1 / 肥満 / 褐色脂肪 |
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| Outline of Final Research Achievements |
Brown adipocytes play a specific role for heat production by dissipating caloric energy, contributing to body temperature and weight regulation; however, the mechanism of brown adipogenesis remains to be fully understood. We recently found that cellular repressor of E1A-stimulated genes 1 (Creg1) is a novel regulator of brown adipogenesis. In the present study, we investigated the action mechanism of Creg1 and its physiological role. As the results, we found that Creg1 binds to IGF2R and stimulated Ucp1 transcription in vitro. In addition, we created aP2-Creg1-Tg mice, in which brown/beige adipogenesis was prominent in adipose tissues compared to wild-type mice. These results suggested that Creg1 acts as a transcriptional regulator for brown adipogenesis through autocrine/paracrine mechanism.
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