Enantioselective Aerobic Alcohol Oxidation Using Chiral Ligand-Hybridized Nitroxyl Radical/Copper Catalysis
| Project/Area Number |
15K07848
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
Sasano Yusuke 東北大学, 薬学研究科, 助教 (10636400)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | アルコール酸化反応 / ニトロキシルラジカル / 酸化的速度論的光学分割反応 / 化学選択性 / 化学選択的酸化反応 |
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| Outline of Final Research Achievements |
Development of enantioselective aerobic alcohol oxidation using chiral ligand-hybridized nitroxyl radical/copper catalysis has been investigated. After evaluation of the catalytic activities of newly synthesized chiral ligand-hybridized nitroxyl radicals, we have identified highly enantioselective conditions for oxidative kinetic resolution of racemic secondary alcohols. (49% conversion, 90% ee (s value 75)). The optimum conditions tolerate various oxidation-labile functional groups, such as methoxyphenyl, aniline, and sulfide groups.
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Report
(4 results)
Research Products
(14 results)
