| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Development of enantioselective aerobic alcohol oxidation using chiral ligand-hybridized nitroxyl radical/copper catalysis has been investigated. After evaluation of the catalytic activities of newly synthesized chiral ligand-hybridized nitroxyl radicals, we have identified highly enantioselective conditions for oxidative kinetic resolution of racemic secondary alcohols. (49% conversion, 90% ee (s value 75)). The optimum conditions tolerate various oxidation-labile functional groups, such as methoxyphenyl, aniline, and sulfide groups.
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